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Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

机译:马鹿茸的水提物通过调节毛囊的毛发周期和细胞增殖来促进毛发生长

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摘要

Deer antlers are the only mammalian appendage capable of regeneration. We aimed to investigate the effect of red deer antler extract in regulating hair growth, using a mouse model. The backs of male mice were shaved at eight weeks of age. Crude aqueous extracts of deer antler were prepared at either 4°C or 100°C and injected subcutaneously to two separate groups of mice (n = 9) at 1 mL/day for 10 consecutive days, with water as a vehicle control group. The mice skin quantitative hair growth parameters were measured and 5-bromo-2-deoxyuridine was used to identify label-retaining cells. We found that, in both the 4°C and the 100°C deer antler aqueous extract-injection groups, the anagen phase was extended, while the number of BrdU-incorporated cells was dramatically increased. These results indicate that deer antler aqueous extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.
机译:鹿角是唯一能够再生的哺乳动物附肢。我们旨在使用小鼠模型研究马鹿茸提取物在调节头发生长中的作用。雄性小鼠的背部在八周龄时剃光。在4°C或100°C下制备鹿角粗提取物,并以10毫升/天的剂量皮下注射到两组单独的小鼠(n = 9)中,连续10天,其中水作为媒介物对照组。测量小鼠皮肤定量毛发生长参数,并使用5-溴-2-脱氧尿苷鉴定保留标签的细胞。我们发现,在4°C和100°C的鹿茸含水提取物注射组中,生长期都得到了延长,而掺入BrdU的细胞数量则显着增加。这些结果表明,鹿茸含水提取物通过延长生长期并调节毛囊区域的细胞增殖来促进毛发生长。

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