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Efficacy of screens in removing long fibers from an aerosol stream – sample preparation technique for toxicology studies

机译：筛网从气溶胶流中去除长纤维的功效–毒理学研究的样品制备技术

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Fiber dimension (especially length) and biopersistence are thought to be important variables in determining the pathogenicity of asbestos and other elongate mineral particles. In order to prepare samples of fibers for toxicology studies, it is necessary to develop and evaluate methods for separating fibers by length in the micrometer size range. In this study, we have filtered an aerosol of fibers through nylon screens to investigate whether such screens can efficiently remove the long fibers (L >20 μm, a typical macrophage size) from the aerosol stream. Such a sample, deficient in long fibers, could then be used as the control in a toxicology study to investigate the role of length. A well-dispersed aerosol of glass fibers (a surrogate for asbestos) was generated by vortex shaking a Japan Fibrous Material Research Association (JFMRA) glass fiber powder. Fibers were collected on a mixed cellulose ester (MCE) filter, imaged with phase contrast microscopy (PCM) and lengths were measured. Length distributions of the fibers that penetrated through various screens (10, 20 and 60 μm mesh sizes) were analyzed; additional study was made of fibers that penetrated through double screen and centrally blocked screen configurations. Single screens were not particularly efficient in removing the long fibers; however, the alternative configurations, especially the centrally blocked screen configuration, yielded samples substantially free of the long fibers.
机译：纤维尺寸（尤其是长度）和生物持久性被认为是确定石棉和其他细长矿物颗粒致病性的重要变量。为了制备用于毒理学研究的纤维样品，有必要开发和评估在微米尺寸范围内按长度分离纤维的方法。在这项研究中，我们通过尼龙筛过滤了纤维的气溶胶，以研究这种筛是否可以有效地从气溶胶流中去除长纤维（L> 20μm，典型的巨噬细胞大小）。这样的样品，缺乏长纤维，然后可以用作毒理学研究中的对照，以研究长度的作用。通过涡旋摇晃日本纤维材料研究协会（JFMRA）玻璃纤维粉末，生成了分散良好的玻璃纤维气雾剂（石棉替代品）。将纤维收集在混合纤维素酯（MCE）过滤器上，用相差显微镜（PCM）成像并测量长度。分析了穿过各种筛网（10、20和60μm筛孔尺寸）的纤维的长度分布；另外的研究是通过双筛和中心阻塞筛配置的纤维。单筛网在去除长纤维方面不是特别有效。然而，可替代的配置，特别是中央封闭的筛网配置，产生了基本上没有长纤维的样品。

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