• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The Journal of Experimental Medicine >Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System
【2h】

Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System

机译：人类神经生长因子通过切换中枢神经系统内T型辅助细胞1型和2型细胞因子的平衡来保护普通Mar猴免受自身免疫性脑脊髓炎

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which an immune attack directed against myelin constituents causes myelin destruction and death of oligodendrocytes, the myelin-producing cells. Here, the efficacy of nerve growth factor (NGF), a growth factor for neurons and oligodendrocytes, in promoting myelin repair was evaluated using the demyelinating model of experimental allergic encephalomyelitis (EAE) in the common marmoset. Surprisingly, we found that NGF delayed the onset of clinical EAE and, pathologically, prevented the full development of EAE lesions. We demonstrate by immunocytochemistry that NGF exerts its antiinflammatory effect by downregulating the production of interferon γ by T cells infiltrating the CNS, and upregulating the production of interleukin 10 by glial cells in both inflammatory lesions of EAE and normal-appearing CNS white matter. Thus, NGF, currently under investigation in human clinical trials as a neuronal trophic factor, may be an attractive candidate for therapy of autoimmune demyelinating disorders.
机译：多发性硬化症是中枢神经系统（CNS）的脱髓鞘疾病，其中针对髓磷脂成分的免疫攻击导致髓磷脂破坏并破坏了产生髓鞘的细胞少突胶质细胞。在这里，使用实验性变应性脑脊髓炎（EAE）在普通my猴中的脱髓鞘模型，评估了神经生长因子（NGF）（神经元和少突胶质细胞的生长因子）在促进髓鞘修复中的功效。令人惊讶地，我们发现NGF延迟了临床EAE的发作，并且在病理上阻止了EAE病变的完全发展。我们通过免疫细胞化学证明，NGF通过下调渗透到CNS中的T细胞干扰素γ的产生，并通过上调EAE和正常出现的CNS白质中的神经胶质细胞的白细胞介素10的产生来发挥其抗炎作用。因此，目前正在人类临床试验中作为神经营养因子进行研究的NGF，可能是治疗自身免疫性脱髓鞘疾病的诱人候选物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号