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Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking

机译：偏好嗜酒（P）和高饮酒（HAD）的大鼠的定期饮用酒精饮料：模拟青少年和成年狂饮般的饮酒

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摘要

Binge alcohol drinking continues to be a public health concern among today’s youth and young adults. Moreover, an early onset of alcohol use, which usually takes the form of binge drinking, is associated with a greater risk for developing alcohol use disorders. Given this, it is important to examine this behavior in rat models of alcohol abuse and dependence. Toward that end, the objective of this article is to review findings on binge-like drinking by selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats. As reviewed elsewhere in this special issue, the P line meets all, and the HAD line meets most, of the proposed criteria for an animal model of alcoholism. One model of binge drinking is scheduled ethanol access during the dark cycle, which has been used by our laboratory for over 20 years. Our laboratory has also adopted a protocol involving the concurrent presentation of multiple ethanol concentrations. When this protocol is combined with limited access, ethanol intake is maximized yielding blood ethanol levels (BELs) in excess, sometimes greatly in excess, of 80 mg%. By extending these procedures to include multiple scheduled ethanol access sessions during the dark cycle for 5 consecutive days/week, P and HAD rats consume in 3 or 4 h as much as, if not more than, the amount usually consumed in a 24-h period. Under certain conditions, using the multiple scheduled access procedure, BELs exceeding 200 mg% can be achieved on a daily basis. An overview of findings from studies with other selectively bred, inbred, and outbred rats places these findings in the context of the existing literature. Overall, the findings support the use of P and HAD rats as animal models to study binge-like alcohol drinking and reveal that scheduled access procedures will significantly increase ethanol intake by other rat lines and strains as well.
机译：在当今的年轻人中，酗酒仍然是公共健康问题。而且，通常以暴饮暴食的形式开始的较早饮酒与发生饮酒障碍的更大风险相关。鉴于此，重要的是在酒精滥用和依赖性的大鼠模型中检查这种行为。为此，本文的目的是通过选择性繁殖酒精偏好（P）和高酒精饮用（HAD）品系来回顾关于暴饮暴饮的研究结果。正如本期特刊中其他地方所评论的那样，对于酒精中毒动物模型，P品系能够满足所有提议的标准，而HAD品系能够满足大多数提议的标准。一种暴饮暴食的模式是在黑暗周期内计划使用乙醇，这已被我们的实验室使用了20多年。我们的实验室还采用了涉及同时显示多种乙醇浓度的方案。当此协议与有限的访问权限结合使用时，乙醇摄入量将最大化，从而使血液中的乙醇水平（BELs）超过80 mg％，有时甚至大大超过80 mg％。通过将这些程序扩展为包括连续5天/周的暗周期内的多个计划的乙醇获取会话，P和HAD大鼠在3或4小时内的消耗量相当于或通常在24小时内消耗的量，如果不多的话期。在某些条件下，使用多重计划访问程序，每天可以达到超过200 mg％的BEL。对其他选择性繁殖，近交和近交大鼠的研究结果的概述将这些发现与现有文献相结合。总体而言，这些发现支持使用P和HAD大鼠作为动物模型来研究暴饮性饮酒，并揭示了计划的获取程序也将显着增加其他大鼠品系和品系的乙醇摄入量。

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