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首页> 外文期刊>Alcohol >Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: Modeling adolescent and adult binge-like drinking
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Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: Modeling adolescent and adult binge-like drinking

机译：通过酒精偏好（p）和高酒精饮用（have）大鼠的预定接入酒精饮用（p）：造型青少年和成人狂犬病饮用

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Binge alcohol drinking continues to be a public health concern among today's youth and young adults. Moreover, an early onset of alcohol use, which usually takes the form of binge drinking, is associated with a greater risk for developing alcohol use disorders. Given this, it is important to examine this behavior in rat models of alcohol abuse and dependence. Toward that end, the objective of this article is to review findings on binge-like drinking by selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats. As reviewed elsewhere in this special issue, the P line meets all, and the HAD line meets most, of the proposed criteria for an animal model of alcoholism. One model of binge drinking is scheduled ethanol access during the dark cycle, which has been used by our laboratory for over 20 years. Our laboratory has also adopted a protocol involving the concurrent presentation of multiple ethanol concentrations. When this protocol is combined with limited access, ethanol intake is maximized yielding blood ethanol levels (BELs) in excess, sometimes greatly in excess, of 80 mg%. By extending these procedures to include multiple scheduled ethanol access sessions during the dark cycle for 5 consecutive days/week, P and HAD rats consume in 3 or 4 h as much as, if not more than, the amount usually consumed in a 24 h period. Under certain conditions, using the multiple scheduled access procedure, BELs exceeding 200 mg% can be achieved on a daily basis. An overview of findings from studies with other selectively bred, inbred, and outbred rats places these findings in the context of the existing literature. Overall, the findings support the use of P and HAD rats as animal models to study binge-like alcohol drinking and reveal that scheduled access procedures will significantly increase ethanol intake by other rat lines and strains as well.
机译：狂欢酒精饮酒仍然是当今青年和年轻成年人之间的公共卫生问题。此外，醇类使用的早期发作，通常采用狂犬病饮酒的形式，与发展醇类使用障碍的风险更大。鉴于这一点，重要的是要检查酒精滥用和依赖的大鼠模型中的这种行为。为此，本文的目的是通过选择性地培育酒精偏好（P）和高级酒精（HAT）大鼠的大鼠来审查对狂犬病饮酒的结果。在此特殊问题的其他地方审查，P线符合所有人，而且大部分符合大多数人的酗酒动物模型的拟议标准。在黑暗循环期间调度了一种狂暴饮酒模型，其实验室已被我们的实验室使用超过20年。我们的实验室还采用了一种涉及多种乙醇浓度的同时呈递的协议。当该方案与有限的接入结合时，乙醇摄入量最大化，产生过量的血液乙醇水平（BEL），有时大大超过80mg％。通过将这些程序扩展到在黑暗周期内包括多个预定的乙醇接入会话，连续5天/周，P并且大鼠在3或4小时内消耗，如果不超过，通常在24小时内消耗的量。在某些条件下，使用多个预定的访问程序，可以每天实现超过200 mg％的BEL。在现有文献的背景下将这些发现的研究结果概述了研究。总体而言，调查结果支持使用P并将大鼠作为动物模型研究狂犬病的酒精饮酒，并揭示预定的访问程序将显着增加其他大鼠线和菌株的乙醇摄入量。

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