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首页> 外文期刊>Alcohol >The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats - Animal models of alcoholism
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The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats - Animal models of alcoholism

机译：嗜酒（P）和高饮酒（HAD）大鼠-酒精中毒的动物模型

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The objective of this article is to review the literature on the utility of using the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free-choice situation to produce BACs between 50 and 200 mg%. The HAD1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders.
机译：本文的目的是回顾有关在研究成人和青少年高饮酒，渴望类似饮酒的研究中使用选择性繁殖的偏爱酒精的（P）和高酒精饮用（HAD）品系的实用性的文献。行为，以及酒精与其他药物的共同滥用。大鼠的P系符合关于酒精中毒动物模型的所有最初提出的标准。此外，P鼠表现出较高的寻酒行为，在反复饮酒条件下表现出酒精剥夺作用（ADE），在青春期消耗的乙醇量与成年时所消耗的乙醇相当，并且会共同滥用乙醇和尼古丁。 P线还表现出过度的狂饮般的饮酒，每天达到200 mg％的血液酒精浓度（BAC）。大鼠的HAD复制品系没有像P大鼠那样被广泛研究。 HAD1,2大鼠满足酒精中毒动物模型的几个标准，例如，这些大鼠将在自由选择的情况下自愿消耗乙醇，以产生50至200 mg％的BAC。在反复复发的条件下，HAD1,2大鼠也表现出ADE，并且在成年期表现出与成人相同的乙醇摄入水平。总体而言，P和HAD1,2大鼠具有归因于早期酒精中毒的特征，可用于研究酒精使用障碍的各个方面。

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