• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Immature Mice are More Susceptible to the Detrimental Effects of High Fat Diet on Cancellous Bone in the Distal Femur
【2h】

Immature Mice are More Susceptible to the Detrimental Effects of High Fat Diet on Cancellous Bone in the Distal Femur

机译：不成熟的小鼠更容易受到高脂饮食对股骨远端松质骨的不利影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

With the increasing prevalence of obesity among children and adolescents, it is imperative to understand the implications of early diet-induced obesity on bone health. We hypothesized that cancellous bone of skeletally immature mice is more susceptible to the detrimental effects of a high fat diet (HFD) than mature mice, and that removing excess dietary fat will reverse these adverse effects. Skeletally immature (5 weeks old) and mature (20 weeks old) male C57BL/6J mice were fed either a HFD (60% kcal fat) or low fat diet (LFD; 10% kcal fat) for 12 weeks, at which point, the trabecular bone structure in the distal femoral metaphysis and third lumbar vertebrae were evaluated by micro-computed tomography. The compressive strength of the vertebrae was also measured. In general, the HFD led to deteriorations in cancellous bone structure and compressive biomechanical properties in both age groups. The HFD-fed immature mice had a greater decrease in trabecular bone volume fraction (BVF) in the femoral metaphysis, compared to mature mice (p=0.017 by 2-way ANOVA). In the vertebrae, however, the HFD led to similar reductions in BVF and compressive strength in the two age groups. When mice on the HFD were switched to a LFD (HFD:LFD) for an additional 12 weeks, the femoral metaphyseal BVF in immature mice showed no improvements, whereas the mature mice recovered their femoral metaphyseal BVF to that of age-matched lean controls. The vertebral BVF and compressive strength of HFD:LFD mouse bones, following diet correction, were equivalent to those of LFD:LFD mice in both age groups. These data suggest that femoral cancellous metaphyseal bone is more susceptible to the detrimental effects of HFD before skeletal maturity and is less able to recover after correcting the diet. Negative effects of HFD on vertebrae are less severe and can renormalize with LFD:LFD mice after diet correction, in both skeletally immature and mature animals.
机译：随着儿童和青少年肥胖症的患病率增加，必须了解早期饮食引起的肥胖症对骨骼健康的影响。我们假设骨骼不成熟的小鼠的松质骨比高龄小鼠更容易受到高脂饮食（HFD）的有害影响，并且去除多余的饮食脂肪会逆转这些不利影响。骨骼不成熟（5周大）和成熟（20周大）的雄性C57BL / 6J小鼠接受HFD（60％大卡脂肪）或低脂饮食（LFD； 10％大卡脂肪）喂养12周，通过显微计算机断层扫描评估股骨远端干meta端和第三腰椎的小梁骨结构。还测量了椎骨的抗压强度。通常，HFD导致两个年龄组的松质骨结构和压缩生物力学性能下降。与成熟小鼠相比，由HFD喂养的未成熟小鼠的股骨干physi端的小梁骨体积分数（BVF）降低幅度更大（2-way ANOVA显示p = 0.017）。但是，在椎骨中，HFD导致两个年龄组的BVF和抗压强度都有相似的下降。当将HFD上的小鼠切换为LFD（HFD：LFD）额外的12周时，未成熟小鼠的股骨干phy端BVF没有改善，而成熟小鼠的股骨干phy端BVF恢复到与年龄相匹配的瘦对照组。饮食校正后，HFD：LFD小鼠骨骼的椎体BVF和抗压强度在两个年龄组均与LFD：LFD小鼠相同。这些数据表明，股骨松质干phy端骨在骨骼成熟之前更容易受到HFD的有害影响，并且在纠正饮食后恢复的能力较弱。在骨骼未成熟和成熟的动物中，饮食校正后，HFD对椎骨的负面影响较小，可以通过LFD：LFD小鼠使其恢复正常。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号