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Is blunted cardiovascular reactivity in depression mood-state dependent? A comparison of major depressive disorder remitted depression and healthy controls

机译：抑郁情绪状态是否使心血管反应迟钝？主要抑郁症缓解的抑郁症与健康对照的比较

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Prior work has repeatedly demonstrated that people who have current major depression exhibit blunted cardiovascular reactivity to acute stressors (e.g., ). A key question regards the psychobiological basis for these deficits, including whether such deficits are depressed mood-state dependent or whether these effects are trait-like and are observed outside of depression episodes invulnerable individuals. To examine this issue, we assessed cardiovascular reactivity to a speech stressor task and a forehead cold pressor in 50 individuals with current major depressive disorder (MDD), 25 with remitted major depression (RMD), and 45 healthy controls. Heart rate (HR), blood pressure and impedance cardiography were assessed and analyses controlled for BMI and sex. Significant group effects were found for SBP, HR, and PEP for the speech preparation period and HR, CO, and PEP during the speech. For each of these parameters, only the MDD group exhibited attenuated reactivity as well as impaired SBP recovery. Reactivity and recovery in the RMD group more closely resembled the healthy controls. Speeches given by the MDD group were rated as less persuasive than the RMD or healthy controls' speeches. No significant differences were found for the cold pressor. Blunted cardiovascular reactivity and impaired recovery in current major depression may be mood-state dependent phenomena and may be more reflective of motivational deficits than deficits in the physiological integrity of the cardiovascular system.
机译：先前的工作反复证明当前患有严重抑郁症的人对急性应激源（例如）的心血管反应减弱。一个关键问题涉及这些缺陷的心理生物学基础，包括这些缺陷是否与沮丧的情绪状态有关，或者这些影响是否是特质样的，并且在无情的抑郁发作个体之外观察到。为了研究这个问题，我们评估了50名目前患有重度抑郁症（MDD），25名缓解性重度抑郁症（RMD）和45名健康对照者的语音响应压力和额头冷压的心血管反应性。评估心率（HR），血压和阻抗心动图，并控制BMI和性别的分析。在语音准备期间，SBP，HR和PEP以及语音期间的HR，CO和PEP被发现具有显着的群体效应。对于这些参数中的每一个，仅MDD组显示出减弱的反应性以及受损的SBP恢复。 RMD组的反应性和恢复情况与健康对照组更为相似。与RMD或健康对照组的讲话相比，MDD组的讲话缺乏说服力。冷压机没有发现明显差异。在当前的严重抑郁症中，钝化的心血管反应性和恢复能力受损可能是情绪状态依赖性的现象，并且与心血管系统生理完整性的缺陷相比，可能更能反映动机缺陷。

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