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Releasing the Block: Setting Differentiation Free with Mutant IDHInhibitors

机译：释放障碍：使用突变IDH设置无差异抑制剂类

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Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.

机译：IDH1和IDH2中的热点突变会导致分化障碍，从而促进肿瘤发生。最近的两篇论文报道，靶向突变体IDH1或突变体IDH2的小分子释放了这种分化阻滞和/或阻碍了肿瘤的生长，提供了概念性证据证明突变体IDHs可治疗靶向并且其作用是可逆的。

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期刊名称 other
作者
Christopher J. Pirozzi; Zachary J. Reitman; Hai Yan;
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年(卷),期 -1(23),5
年度 -1
页码 570–572
总页数 5
原文格式 PDF
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专利

1. Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors [J] . PirozziC., ReitmanZ., YanH. Cancer Cell . 2013,第5期

机译：释放障碍：使用突变的IDH抑制剂释放差异
2. Sexual differentiation in Mucor: Trisporic acid response mutants and mutants blocked in zygospore development☆ [J] . Tilmann Wurtz, Harald Jockusch Developmental biology . 1975,第2期

机译：Mucor中的性别分化：三孢子酸反应突变体和受精孢子发育受阻的突变体☆
3. Control mechanisms regulating gene expression during normal differentiation of myeloid leukemic cells: Differentiation defective mutants blocked in mRNA production and mRNA translation☆ [J] . Barbara Hoffman-Liebermann, Dan Liebermann, Leo Sachs Developmental biology . 1981,第2期

机译：髓系白血病细胞正常分化过程中调控基因表达的调控机制：mRNA生产和mRNA翻译受阻的分化缺陷突变体☆
4. An improved setting-free power swing blocking scheme using local end information [C] . Iyer Shriram Ganeshan, Manas Kumar Jena, Bijaya Ketan Panigrahi 2018 IEEMA Engineer Infinite Conference . 2018

机译：使用本地终端信息的改进的免设置功率摆幅阻止方案
5. Biochemical characterization of Saccharomyces cerevisiae mutants blocked at endosome-to-vacuole trafficking by floatation centrifugation [D] . Sao, Dyna 2003

机译：酿酒酵母突变体的生化特性通过浮选离心阻止了从内体到真空的运输
6. Mutants of Streptococcus suis types 1 and 2 impaired in expression of muramidase-released protein and extracellular protein induce disease in newborn germfree pigs. [O] . H E Smith, U Vecht, H J Wisselink, 1996

机译：1型和2型猪链球菌突变株的muramidase释放蛋白和细胞外蛋白表达受损从而导致新生无菌猪患病。
7. Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors [O] . Pirozzi Christopher J., Reitman Zachary J., Yan Hai 2013

机译：释放障碍：使用突变的IDH抑制剂释放差异

Releasing the Block: Setting Differentiation Free with Mutant IDHInhibitors

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