Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors

PirozziC.; ReitmanZ.; YanH.

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Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors

机译：释放障碍：使用突变的IDH抑制剂释放差异

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Hotspot mutations in IDH1 and IDH2 cause a differentiation block that can promote tumorigenesis. Two recent papers reported that small molecules targeting mutant IDH1 or mutant IDH2 release this differentiation block and/or impede tumor growth, providing a proof-of-concept that mutant IDHs are therapeutically targetable and that their effects are reversible.

机译：IDH1和IDH2中的热点突变会导致分化障碍，从而促进肿瘤发生。最近的两篇论文报道，靶向突变体IDH1或突变体IDH2的小分子释放了这种分化阻滞和/或阻碍了肿瘤的生长，提供了概念性证据证明突变体IDHs可治疗靶向并且其作用是可逆的。

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《Cancer Cell》 |2013年第5期|共3页
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PirozziC.; ReitmanZ.; YanH.;
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正文语种 eng
中图分类肿瘤学;
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1. Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors [J] . PirozziC., ReitmanZ., YanH. Cancer Cell . 2013,第5期

机译：释放障碍：使用突变的IDH抑制剂释放差异
2. First-in-class, oral mutant IDH2 inhibitor reverses differentiation block in acute myeloid leukaemia to produce clinically meaningful responses [J] . Paresh Vyas Experimental Hematology: Official Publication of the International Society for Experimental Hematology . 2017,第期

机译：一流的，口服突变体IDH2抑制剂在急性髓性白血病中逆转分化块，以产生临床有意义的反应
3. Mutant IDH inhibits HNF-4 alpha to block hepatocyte differentiation and promote binary cancer (vol 513, 110, 2014) [J] . Saha Supriya K., Parachoniak Christine A., Ghanta Krishna S., Nature . 2015,第7580期

机译：突变IDH抑制HNF-4α阻断肝细胞分化并促进二元癌（vol 513，110，2014）
4. QUANTIFICATION OF SUBSTRATE AND INHIBITOR BINDING TO WILD TYPE AND MUTANT ISOCITRATE DEHYDROGENASE (IDH1) BY NON-DENATURING MASS SPECTROMETRY [C] . Victor Mikhailov, Shuang Liu, Christopher Schofield, International Mass Spectrometry Conference . 2018

机译：通过非变性质谱法定量基质和抑制剂与野生型和突变体相酯脱氢酶（IDH1）的结合
5. Particle fabrication and delivery systems for controlled release of bumped kinase inhibitors (BKIs) for malaria transmission blocking [D] . Yacoob, Christina S. 2013

机译：用于控制释放促性激酶抑制剂（BKI）的疟疾传播阻断的颗粒制造和递送系统
6. Releasing the Block: Setting Differentiation Free with Mutant IDHInhibitors [O] . Christopher J. Pirozzi, Zachary J. Reitman, Hai Yan -1

机译：释放障碍：使用突变IDH设置无差异抑制剂类
7. Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors [O] . Pirozzi Christopher J., Reitman Zachary J., Yan Hai 2013

机译：释放障碍：使用突变的IDH抑制剂释放差异

Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors

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