In a time of scientific and technological developments and budgetary constraints, the National Cancer Institute (NCI)’s Provocative Questions (PQ) Project offers a novel funding mechanism for cancer epidemiologists. We reviewed the purposes underlying the PQ Project, present information on the contributions of epidemiologic research to the current PQ portfolio, and outline opportunities that the cancer epidemiology community might capitalize on to advance a research agenda that spans a translational continuum from scientific discoveries to population health impact.
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