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Cancer Risk of Anti-TNF-α at Recommended Doses in Adult Rheumatoid Arthritis: A Meta-Analysis with Intention to Treat and per Protocol Analyses

机译：抗TNF-α的癌症风险在成人类风湿关节炎推荐剂量的meta分析用心对待每协议分析

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BackgroundThe risk of malignancies on TNF-α antagonists is controversial. The aim of this survey was to assess cancer risk on TNF-α antagonists in adult rheumatoid arthritis patients, including the five marketed drugs (infliximab, etanercept, adalimumab, golimumab and certolizumab) used in line with the New Drug Application. Furthermore, the relative interest of modified intention to treat or per protocol analyses to assess such sparse events remains unknown.

机译：背景TNF-α拮抗剂发生恶性肿瘤的风险是有争议的。这项调查的目的是评估成年类风湿关节炎患者使用TNF-α拮抗剂的癌症风险，包括与新药申请一致使用的五种市售药物（英夫利昔单抗，依那西普，阿达木单抗，戈利木单抗和赛妥珠单抗）。此外，治疗或按方案分析以评估此类稀疏事件的改良意向的相对兴趣仍然未知。

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期刊名称 other
作者
Guillaume Moulis; Agnès Sommet; Johana Béné; François Montastruc; Laurent Sailler; Jean-Louis Montastruc; Maryse Lapeyre-Mestre;
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年(卷),期 -1(7),11
年度 -1
页码 e48991
总页数 7
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专利

1. Do anti-TNF-α drugs increase cancer risk in rheumatoid arthritis patients? [J] . David A Clark Inflammopharmacology . 2013,第2期

机译：抗TNF-α药物会增加类风湿关节炎患者的癌症风险吗？
2. Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose [J] . Akira Hashiramoto, Kazuko Shiozawa, Yasushi Tanaka, Modern Rheumatology . 2009,第6期

机译：甲氨蝶呤治疗类风湿关节炎的前瞻性研究，按照政府推荐的8 mg /周剂量合理治疗
3. Sustained Beneficial Effects of a Protocolized Treat-to-Target Strategy in Very Early Rheumatoid Arthritis: Three-Year Results of the Dutch Rheumatoid Arthritis Monitoring Remission Induction Cohort [J] . Vermeer M., Kuper H. H., Moens H. J. Bernelot, Arthritis care & research . 2013,第8期

机译：在非常早期的类风湿性关节炎中持续有益的疗效效果：荷兰类风湿性关节炎监测缓解诱导队列的三年结果
4. Insulin resistance in rheumatoid arthritis: the impact of the anti-TNF-α therapy [C] . Miguel A. Gonzalez-Gay, Carlos Gonzalez-Juanatey, Tomas R. Vazquez-Rodriguez, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：类风湿性关节炎中胰岛素抵抗力：抗TNF-α治疗的影响
5. A comparative study of quality of life in patients with low-and intermediate-risk prostate cancer treated at a single institution: Stereotactic radiotherapy vs. high dose-rate brachytherapy monotherapy vs. high dose-rate brachytherapy boost [D] . Helou, Joelle. 2017

机译：单一机构治疗的中低危前列腺癌患者生活质量的比较研究：立体定向放疗与高剂量率近距离放射疗法单药疗法与高剂量率近距离放射疗法增强
6. Risk of infections and cardiovascular and venous thromboembolic events associated with JAK inhibitors in rheumatoid arthritis: protocols of two systematic reviews and network meta-analyses [O] . Carlos Alves, Ana Penedones, Diogo Mendes, 2020

机译：与jak抑制剂相关的感染和心血管和静脉血栓栓塞事件中的类风湿性关节炎：两个系统评价和网络荟萃分析的协议
7. Cancer risk of anti-TNF-α at recommended doses in adult rheumatoid arthritis: a meta-analysis with intention to treat and per protocol analyses. [O] . Guillaume Moulis, Agnès Sommet, Johana Béné, 2012

机译：在成人类风湿性关节炎中推荐剂量的抗TNF-α的癌症风险：有意治疗和按方案分析的荟萃分析。

Cancer Risk of Anti-TNF-α at Recommended Doses in Adult Rheumatoid Arthritis: A Meta-Analysis with Intention to Treat and per Protocol Analyses

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