首页> 美国卫生研究院文献>other >The high mobility group box: the ultimate utility player of a cell
【2h】

The high mobility group box: the ultimate utility player of a cell

机译:高移动性组框:细胞的终极实用播放机

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

High mobility group (HMG) box proteins are abundant and ubiquitous DNA binding proteins with a remarkable array of functions throughout the cell. The structure of the HMG-box DNA binding domain and general mechanisms of DNA binding and bending have been known for more than a decade. However, new mechanisms that regulate HMG-box protein intracellular translocation, and by which HMG-box proteins recognize DNA with and without sequence specificity, have only recently been uncovered. This review focuses primarily on the Sry-like HMG box family, HMGB1, and mitochondrial transcription factor A. For these proteins, structural and biochemical studies have shown that HMG-box protein modularity, interactions with other DNA binding proteins and cellular receptors, and post-translational modifications are key regulators of their diverse functions.
机译:高迁移率族(HMG)盒蛋白是丰富且普遍存在的DNA结合蛋白,在整个细胞中具有显着的功能。 HMG-box DNA结合域的结构以及DNA结合和弯曲的一般机制已经有十多年了。然而,调节HMG-box蛋白胞内易位以及HMG-box蛋白识别具有和不具有序列特异性的DNA的新机制直到最近才被发现。这篇综述主要侧重于Sry样HMG盒家族,HMGB1和线粒体转录因子A。对于这些蛋白质,结构和生化研究表明,HMG-box蛋白质模块性,与其他DNA结合蛋白和细胞受体的相互作用,以及-翻译修饰是其多种功能的关键调节剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号