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Effects of Bazedoxifene Acetate with and without Conjugated Equine Estrogens on the Breast of Postmenopausal Monkeys

机译：Bazedoxifene醋酸盐与绝经后猴子乳房乳腺癌的影响

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摘要

ObjectiveConcerns about increased breast cancer risk with estrogen and progestin therapy have led to an increased interest in progestin alternatives. The main objective of this study was to determine if bazedoxifene acetate (BZA), a new selective estrogen receptor modulator (SERM), would antagonize the proliferative and transcriptional effects of conjugated equine estrogens (CEE) in the breast.

机译：目的关于雌激素和孕激素治疗增加乳腺癌风险的担忧已引起人们对孕激素替代药物的兴趣增加。这项研究的主要目的是确定一种新的选择性雌激素受体调节剂（SERM）醋酸巴多昔芬（BZA）是否会拮抗共轭马雌激素（CEE）在乳房中的增殖和转录作用。

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期刊名称 other
作者
Kelly F. Ethun; Charles E. Wood; Thomas C. Register; J. Mark Cline; Susan E. Appt; Thomas B. Clarkson;
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作者单位

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年(卷),期 -1(19),11
年度 -1
页码 0b013e318252e46d
总页数 23
原文格式 PDF
正文语种
中图分类
关键词
Menopause Hormone Therapy Estrogen Selective Estrogen Receptor Modulator Estrogen Receptor Breast;

机译：更年期;激素治疗;雌激素;选择性雌激素受体调节剂;雌激素受体;乳腺癌;

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专利

1. Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys. [J] . Shadoan MK, Anthony MS, Rankin SE, Metabolism: Clinical and Experimental . 2003,第9期

机译：替勃龙和共轭马雌激素在有或没有乙酸甲羟孕酮的情况下对绝经后猴子身体成分和空腹碳水化合物的影响。
2. Effects of conjugated equine estrogen and medroxyprogesterone acetate on lipoprotein(a) and other lipoproteins in japanese postmenopausal women with and without dyslipidemia. [J] . Sumino H, Ichikawa S, Sakamoto H, Hormone research . 2004,第1期

机译：马雌激素和乙酸甲羟孕酮共轭对日本有和没有血脂异常的绝经后妇女脂蛋白（a）和其他脂蛋白的影响。
3. Effects of the conjugated equine estrogen/bazedoxifene Tissue-Selective Estrogen Complex (TSEC) on mammary gland and breast cancer in mice [J] . SongY., SantenR.J., WangJ.-P., Endocrinology . 2012,第12期

机译：马雌激素/巴多昔芬复合组织选择性雌激素复合物（TSEC）对小鼠乳腺和乳腺癌的影响
4. Association of bone mineral density and mammographic breast density in premenopausal and postmenopausal Malaysian women: Study on women with and without breast cancer [C] . Norhayati Mohd Zain, Vengkatha Priya Seriramulu, Kanaga Kumari Chelliah, International Conference on Bio-engineering for Smart Technologies . 2016

机译：绝经前和绝经后马来西亚女性的骨矿物质密度与乳房X线照片乳房密度的关系：有无乳腺癌的女性研究
5. Genotoxic effects induced by equine estrogen metabolites in breast cancer cells. [D] . Liu, Xuemei. 2003

机译：马雌激素代谢产物在乳腺癌细胞中诱导的遗传毒性作用。
6. The Effects of Bazedoxifene Conjugated Equine Estrogens and a Tissue Selective Estrogen Complex (TSEC) Containing Both Bazedoxifene and Conjugated Equine Estrogens on Cerebral Artery Atherosclerosis of Postmenopausal Monkeys [O] . Thomas B. Clarkson, Kelly F. Ethun, Nicholas M. Pajewski, -1

机译：Bazedoxifene共轭马雌激素和同时含有Bazedoxifene和共轭马雌激素的组织选择性雌激素复合物（TSEC）对绝经后猴脑动脉粥样硬化的影响
7. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys [O] . Kelly F. Ethun, Charles E. Wood, Thomas C. Register, 2012

机译：Bazedoxifene醋酸盐与绝经后猴子乳房乳腺癌的影响

Effects of Bazedoxifene Acetate with and without Conjugated Equine Estrogens on the Breast of Postmenopausal Monkeys

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