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Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation Survival and DNA Repair of K562 Cell Line

机译：叉头框m1（FOXm1）基因是一种新的sTaT3转录因子的目标和是必不可少的增殖存活和K562细胞的DNa修复

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The forkhead box (Fox) M1 gene belongs to a superfamily of evolutionarily conserved transcriptional regulators that are involved in a wide range of biological processes, and its deregulation has been implicated in cancer survival, proliferation and chemotherapy resistance. However, the role of FoxM1, the signaling involved in its activation and its role in leukemia are poorly known. Here, we demonstrate by gene promoter analysis, Electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays that FoxM1 is a new target of the STAT3 transcriptional activator. Additionally, FoxM1 is transcriptionally dependent on STAT3 signaling activation. Furthermore, we verified that FoxM1 is crucial for K562 cell proliferation, cell cycle checkpoints and viability and could be related to chemotherapeutic resistance. By microarray analysis, we determined the signaling pathways related to FoxM1 expression and its role in DNA repair using K562 cells. Our results revealed new signaling involved in FoxM1 expression and its role in leukemic cells that elucidate cellular mechanisms associated with the development of leukemia and disease progression.

机译：叉头盒（Fox）M1基因属于进化保守的转录调节子的超家族，涉及许多生物学过程，其去调控作用与癌症的存活，增殖和化疗耐药有关。但是，人们对FoxM1的作用，涉及其激活的信号及其在白血病中的作用知之甚少。在这里，我们通过基因启动子分析，电泳迁移率移动分析（EMSA）和染色质免疫沉淀（ChIP）分析证明，FoxM1是STAT3转录激活因子的新靶标。此外，FoxM1转录依赖于STAT3信号激活。此外，我们证实FoxM1对K562细胞增殖，细胞周期检查点和生存能力至关重要，并且可能与化疗耐药性有关。通过微阵列分析，我们确定了与FoxM1表达有关的信号通路及其在使用K562细胞的DNA修复中的作用。我们的结果揭示了参与FoxM1表达的新信号及其在白血病细胞中的作用，阐明了与白血病的发展和疾病进展相关的细胞机制。

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André L. Mencalha; Renata Binato; Gerson M. Ferreira; Barbara Du Rocher; Eliana Abdelhay;
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年(卷),期 -1(7),10
年度 -1
页码 e48160
总页数 10
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1. The Transcription Factor FOXM1 (Forkhead box Ml): Proliferation-Specific Expression, Transcription Factor Function, Target Genes, Mouse Models, and Normal Biological Roles [J] . Inken Wierstra1 Advances in cancer research. . 2013,第Null期

机译：转录因子FOXM1（前额箱M1）：增殖特异性表达，转录因子功能，靶基因，小鼠模型和正常生物学作用
2. The Transcription Factor FOXM1 (Forkhead box Ml): Proliferation-Specific Expression, Transcription Factor Function, Target Genes, Mouse Models, and Normal Biological Roles [J] . Inken Wierstra1 Advances in cancer research. . 2013,第Null期

机译：转录因子Foxm1（Forkhead Box ML）：细胞增殖表达，转录因子功能，靶基因，小鼠模型和正常的生物作用
3. The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells - ScienceDirect [J] . C.T.D. Kwok, M.H. Leung, J. Qin, Stem cell research . 2016,第3期

机译：Forkhead box转录因子FOXM1是维持人类胚胎干细胞的细胞增殖和抵抗氧化应激所必需的-ScienceDirect
4. MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells [C] . Yukihiko Kitamura Symposium on Mast Cells and Basophils: Development, Activation and Roles in Allergic/Autoimmune Disease . 2005

机译：MITF和SGIGSF：一种基本的转录因子及其肥大细胞的发育和存活的目标粘附分子
5. The cell cycle-dependent regulation of Forkhead box M1 transcriptional activity by phosphorylation. [D] . Chen, Yi-Ju. 2009

机译：通过磷酸化对叉头盒M1转录活性的细胞周期依赖性调节。
6. RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1) Inhibition of the Forkhead Box Protein M1 (FOXM1) and Activation of Forkhead Box Transcription Factor 3A (FOXO3A) [O] . Sven Roßwag, Gitta Thiede, Jonathan P. Sleeman, 2020

机译：RASSF1A通过抑制Yes相关蛋白质1（YAP1）抑制Forkhead盒蛋白M1（FOXM1）的抑制以及FOXO3A）的激活来抑制雌激素依赖性乳腺癌细胞生长。（FOXO3A）的激活
7. Forkhead box M1 (FoxM1) gene is a new STAT3 transcriptional factor target and is essential for proliferation, survival and DNA repair of K562 cell line. [O] . André L Mencalha, Renata Binato, Gerson M Ferreira, 2012

机译：Forkhead box m1（Foxm1）基因是一种新的sTaT3转录因子靶标，对K562细胞的增殖，存活和DNa修复至关重要。

Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation Survival and DNA Repair of K562 Cell Line

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