Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

机译：E-钙粘蛋白和PLEKHA7同时表达对E-钙粘蛋白/ EGFR介导的卵巢癌细胞生长产生负面影响

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BackgroundThe disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related signaling, contrary to the prevailing notion. During tumor progression, epithelial ovarian cancer (EOC) maintains E-cadherin expression and can positively affect EOC cell growth by contributing to PI3K/AKT activation. In polarized epithelia PLEKHA7, a regulator of the zonula adherens integrity, impinges E-cadherin functionality, but its role in EOCs has been never studied.

机译：背景E-钙粘蛋白介导的粘附的破坏被认为是肿瘤进展的重要驱动力。然而，许多研究表明，E-钙粘着蛋白能促进与生长或入侵相关的信号传导，这与流行的观念相反。在肿瘤进展过程中，上皮性卵巢癌（EOC）维持E-钙黏着蛋白表达，并通过促进PI3K / AKT激活而积极影响EOC细胞的生长。在极化的上皮PLEKHA7中，小带的调节子粘附完整性，影响E-钙粘蛋白功能，但从未研究过其在EOC中的作用。

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期刊名称 Journal of Experimental Clinical Cancer Research : CR
作者
Katia Rea; Francesca Roggiani; Loris De Cecco; Francesco Raspagliesi; Maria Luisa Carcangiu; Joyce Nair-Menon; Marina Bagnoli; Ileana Bortolomai; Delia Mezzanzanica; Silvana Canevari; Antonis Kourtidis; Panos Z. Anastasiadis; Antonella Tomassetti;
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作者单位

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年(卷),期 2018(37),-1
年度 2018
页码 146
总页数 16
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
E-cadherin Epithelial ovarian cancer EGFR CDK5 PLEKHA7;

机译：E-钙黏着蛋白;上皮性卵巢癌;EGFR;CDK5;PLEKHA7;

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专利

1. Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells [J] . ChengJ.-C., KlausenC., LeungP.C.K. Cancer letters . 2013,第2期

机译：缺氧诱导因子1α介导表皮生长因子诱导人卵巢癌细胞中E-钙粘蛋白表达下调和细胞侵袭
2. Egr-1 mediates epidermal growth factor-induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells [J] . J-C Cheng, H-M Chang, P C K Leung Oncogene . 2013,第8期

机译：EGR-1介导表皮生长因子诱导通过人卵巢癌细胞中的蛋白质的蛋白酶表达的下调诱导的e-cadherin表达
3. The PI3K/Akt/mTOR signaling pathway mediates insulin-like growth factor 1-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells [J] . LauM.-T., LeungP.C.K. Cancer letters . 2012,第2期

机译：PI3K / Akt / mTOR信号通路介导胰岛素样生长因子1诱导的E-钙粘蛋白下调和卵巢癌细胞的细胞增殖
4. Clinicopathological Significance of E-Cadherin and PCNA Expression in Human Non-Small Cell Lung Cancer [C] . Zhu Yi-fei, Zheng Shi-Ying, Jiang Dong, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：E-钙黏着蛋白和PCNA在人非小细胞肺癌中的临床病理意义
5. Microenvironment regulation of proteinase expression and E-cadherin ectodomain generation in ovarian cancer. [D] . Symowicz, Jaime Elizabeth. 2007

机译：卵巢癌中蛋白酶表达和E-cadherin胞外域生成的微环境调节。
6. Hydrogen Peroxide Mediates EGF-Induced Down-Regulation of E-Cadherin Expression via p38 MAPK and Snail in Human Ovarian Cancer Cells [O] . Jung-Chien Cheng, Christian Klausen, Peter C. K. Leung -1

机译：过氧化氢通过人卵巢癌细胞中的p38 MAPK和Snail介导EGF诱导的E-钙黏着蛋白表达下调。
7. Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth [O] . Katia Rea, Francesca Roggiani, Loris De Cecco, 2018

机译：同时e-cadherin和plekha7表达对e-cadherin / EGFR介导的卵巢癌细胞生长产生负面影响

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

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