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首页> 美国卫生研究院文献>PLoS Neglected Tropical Diseases >Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali West Africa
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Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali West Africa

机译：为西非马里的幼儿模拟疫苗接种潜力以减轻非侵入性沙门氏菌病负担

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BackgroundIn sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where infant vaccination against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in Bamako, Mali, their burden has decreased markedly. In parallel, NTS has become the predominant invasive bacterial pathogen in children aged <5 years. While NTS is believed to be acquired orally via contaminated food/water, epidemiologic studies have failed to identify the reservoir of infection or vehicles of transmission. This has precluded targeting food chain interventions to diminish disease transmission but conversely has fostered the development of vaccines to prevent invasive NTS (iNTS) disease. We developed a mathematical model to estimate the potential impact of NTS vaccination programs in Bamako.
机译：背景技术在撒哈拉以南非洲地区，对疑似浸润性细菌性疾病（例如败血病，脑膜炎）的幼儿进行的系统监测表明，非伤寒沙门氏菌（NTS）是高病死率（〜20％）的主要病原体。在马里的巴马科，为了预防由这些病原体引起的侵袭性疾病，已针对婴幼儿接种了针对b型流感嗜血杆菌（Hib）和肺炎链球菌的疫苗，他们的负担已明显减少。同时，NTS已成为<5岁儿童的主要侵入性细菌病原体。虽然人们认为NTS是通过受污染的食物/水通过口服获得的，但流行病学研究未能确定感染的来源或传播媒介。这就排除了以食物链干预为目标以减少疾病传播的可能性，但是相反地，促进了预防侵袭性NTS（iNTS）疾病的疫苗的开发。我们开发了一个数学模型，以估算巴马科NTS疫苗接种计划的潜在影响。

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