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首页> 外文期刊>PLOS Neglected Tropical Diseases >Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali, West Africa
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Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali, West Africa

机译：造型疫苗接种潜力，以减少幼儿幼儿患儿患有侵袭性非伤寒沙门氏菌疾病的负担

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Background In sub-Saharan Africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal Salmonella (NTS) to be a major pathogen exhibiting high case fatality (~20%). Where infant vaccination against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in Bamako, Mali, their burden has decreased markedly. In parallel, NTS has become the predominant invasive bacterial pathogen in children aged <5 years. While NTS is believed to be acquired orally via contaminated food/water, epidemiologic studies have failed to identify the reservoir of infection or vehicles of transmission. This has precluded targeting food chain interventions to diminish disease transmission but conversely has fostered the development of vaccines to prevent invasive NTS (iNTS) disease. We developed a mathematical model to estimate the potential impact of NTS vaccination programs in Bamako.
机译：撒哈拉以南非洲的背景，系统监测有疑似侵入性细菌疾病的幼儿（例如，败血症，脑膜炎）揭示了非牙龈沙门氏菌（NTS）是表现出高病例（〜20％）的主要病原体。其中引入对嗜血杆菌的婴儿疫苗接种B（hib）和肺炎链球菌疫苗，以防止这些病原体引起的侵入性疾病，如在巴西马里，它们的负担显着下降。平行，NTS已成为<5年龄的儿童的主要侵袭性细菌病原体。虽然据信NTS通过污染的食物/水口服地获得，但流行病学研究未能识别感染或传播车辆的储层。这排除了靶向食物链干预以减少疾病传播，但相反地促进了疫苗的发育，以防止侵入性NTS（INTS）疾病。我们开发了一个数学模型来估计NTS疫苗接种计划在巴马科的潜在影响。

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