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A novel ascaroside controls the parasitic life cycle of the entomopathogenic nematode Heterorhabditis bacteriophora

机译:一种新颖的ascaroside控制昆虫病原线虫异小嗜菌的寄生生命周期

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摘要

Entomopathogenic nematodes survive in the soil as stress-resistant infective juveniles that seek out and infect insect hosts. Upon sensing internal host cues, the infective juveniles regurgitate bacterial pathogens from their gut that ultimately kill the host. Inside the host, the nematode develops into a reproductive adult and multiplies until unknown cues trigger the accumulation of infective juveniles. Here, we show that the entomopathogenic nematode Heterorhabditis bacteriophora uses a small-molecule pheromone to control infective juvenile development. The pheromone is structurally related to the dauer pheromone ascarosides that the free-living nematode Caenorhabditis elegans uses to control its development. However, none of the C. elegans ascarosides are effective in H. bacteriophora, suggesting that there is a high degree of species specificity. Our report is the first to show that ascarosides are important regulators of development in a parasitic nematode species. An understanding of chemical signaling in parasitic nematodes may enable the development of chemical tools to control these species.
机译:昆虫致病线虫在土壤中存活,作为寻求和感染昆虫宿主的抗胁迫感染幼稚。在感测内部宿主提示时,感染幼年症将细菌病原体从它们的肠道重新插入,最终杀死宿主。在主持人内,线虫发展到生殖成人并乘以,直到未知的提示触发感染幼年的积累。在这里,我们表明昆虫致病线虫异端炎炎菌病毒使用小分子信息素来控制感染性幼年发育。信息素在结构上与Dauer信息素蛔虫有关,即自由生的Nematode Caenorhabditis elegans用于控制其发展。然而,C.杆状杆菌的任何C.杆状藻都没有在H. Bacteriophora中有效,表明存在高度的物种特异性。我们的报告是第一个表明Ascarosides是寄生线虫物种中的重要调节因素。在寄生线虫中对化学信号传导的理解可以使化学工具的开发能够控制这些物种。

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