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Synchronization of PER1 protein in Parabrachial nucleus in a natural model of food anticipatory activity

机译：食品预期活动自然模型中Parabrachial细胞核中Per1蛋白的同步

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Rabbit pups represent a natural model of food anticipatory activity (FAA). FAA is the behavioral output of a putative food entrainable oscillator (FEO). It had been suggested that the FEO is comprised of a distributed system of clocks that work in concert in response to gastrointestinal input by food. Scheduled food intake synchronizes several nuclei in the brain, and the hypothalamus has received particular attention. On the contrary, brainstem nuclei, despite being among the brain structures to first receive food cues, have been scarcely studied. Here we analyzed by immunohistochemistry possible oscillation of FOS and PER1 proteins through a complete 24 h cycle in the dorsal vagal complex (DVC) and parabrachial nucleus (PBN) of seven to eight day old rabbit pups scheduled to nurse during the night (02:00) or day (10:00) and also in fasted subjects to explore the possible persistence of oscillations. We found a clear induction of FOS that peaks 1.5 h after nursing in all nuclei studied. PER1 was only synchronized in the PBN, reaching highest values 12 h after nursing. Only PER1 oscillations persisted in fasted subjects. We conclude that the DVC nuclei are probably more related to the transmission of food cues to other brain regions but that the PBN participates in the integration of information essential for FAA. Our results support previous findings suggesting that the DVC nuclei, but not PBN, are not essential for FAA. We suggest that PBN is a key component of the proposed distributed system of clocks involved in FAA.
机译：兔子幼崽代表食物预期活动的自然模型（FAA）。 FAA是推定食品夹发型振荡器（FEO）的行为输出。已经提出，FEO由响应食物的胃肠投入而协同工作的时钟分布式系统。预定的食物摄入同步大脑中的几个细胞核，下丘脑已接受特别关注。相反，尽管在首次接受食物提示的大脑结构中，但仍然几乎已经研究过脑干核。在这里，我们通过在夜间的背部迷走复合物（DVC）和腹腔内核（PBN）中的完整24h循环来分析FOS和PER1蛋白的振荡，七到八天的兔子幼崽，计划在夜间为护理（02:00 ）或日（10:00）以及禁食的受试者探讨了振荡可能的持久性。我们发现在所有核中护理后达到1.5小时的FOS明确诱导。 PER1仅在PBN中同步，护理后12小时达到最高值。只在禁食主题中持久的截面振荡。我们得出结论，DVC核可能与其他大脑地区的食品提示传递有关，但PBN参与FAA所必需的信息的整合。我们的结果支持以前的研究结果表明DVC核，但不是PBN，对FAA不为必要。我们建议PBN是FAA所涉及的拟议的分布式系统的关键组成部分。

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