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首页> 外文期刊>The European Journal of Neuroscience >Synchronization of PER1 protein in parabrachial nucleus in a natural model of food anticipatory activity
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Synchronization of PER1 protein in parabrachial nucleus in a natural model of food anticipatory activity

机译：预期活动自然模型中臂臂旁核中PER1蛋白的同步化

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Rabbit pups represent a natural model of food anticipatory activity (FAA). FAA is the behavioral output of a putative food entrainable oscillator (FEO). It had been suggested that the FEO is comprised of a distributed system of clocks that work in concert in response to gastrointestinal input by food. Scheduled food intake synchronizes several nuclei in the brain, and the hypothalamus has received particular attention. On the contrary, brainstem nuclei, despite being among the brain structures to first receive food cues, have been scarcely studied. Here we analysed by immunohistochemistry possible oscillation of FOS and PER1 proteins through a complete 24-h cycle in the dorsal vagal complex (DVC) and parabrachial nucleus (PBN) of 7-8-day-old rabbit pups scheduled to nurse during the night (02:00h) or day (10:00h), and also in fasted subjects to explore the possible persistence of oscillations. We found a clear induction of FOS that peaks 1.5h after nursing in all nuclei studied. PER1 was only synchronized in the PBN, reaching highest values 12h after nursing. Only PER1 oscillations persisted, with a shift, in fasted subjects. We conclude that the DVC nuclei are probably more related to the transmission of food cues to other brain regions, but that the PBN participates in the integration of information essential for FAA. Our results support previous findings suggesting that the DVC nuclei, but not PBN, are not essential for FAA. We suggest that PBN is a key component of the proposed distributed system of clocks involved in FAA.
机译：兔子幼崽代表食物预期活动（FAA）的天然模型。 FAA是假定的食物夹带振荡器（FEO）的行为输出。已经提出，FEO由分布式时钟系统组成，该时钟系统响应食物胃肠输入而协同工作。预定的食物摄入使大脑中的多个核同步，下丘脑受到了特别的关注。相反，尽管脑干核是首先接受食物线索的脑部结构之一，但很少进行研究。在这里，我们通过免疫组织化学分析了FOS和PER1蛋白可能在整个夜间的24小时循环中的迷走神经复合物（DVC）和臂旁核（PBN）的完整的24小时循环，这7-8天大的兔子小狗计划在夜间进行哺乳（ 02：00h）或一天（10：00h），以及在禁食的受试者中探索振荡的可能持久性。我们发现在研究的所有细胞核中，FOS的诱导明显在护理后1.5小时达到峰值。 PER1仅在PBN中同步，在护理后12h达到最高值。在禁食的受试者中，只有PER1振荡持续并发生变化。我们得出结论，DVC核可能与食物线索向其他大脑区域的传播更为相关，但是PBN参与了FAA必不可少的信息整合。我们的结果支持以前的发现，表明DFA核而不是PBN对FAA并不是必不可少的。我们建议PBN是FAA涉及的提议的分布式时钟系统的关键组成部分。

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