No Acquisition: a New Ambition for HIV Vaccine Development?

机译：无重大收购：艾滋病毒疫苗研制新的野心？

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Development of a safe and effective prophylactic HIV-1 vaccine presents unique challenges. The pessimism following the failure of two HIV-1 vaccine concepts in clinical trials, HIV-1 gp120 and an adenovirus-based approach to induce only cellular immune responses, has been replaced by cautious optimism engendered by the RV144 trial outcome, the isolation of several new broadly reactive neutralizing monoclonal antibodies, and recent primate model data indicating prevention of viral acquisition by active or passive immunization. Intense efforts are underway to optimize immunogen design, adjuvants, and the tools for preclinical evaluation of candidate vaccines in primates, where correlates of protection can be examined in detail – as proof-of-concept for clinical trials.

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Samir K. Lakhashe; Guido Silvestri; Ruth M. Ruprecht;
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年(卷),期 -1(1),4
年度 -1
页码 246–253
总页数 13
原文格式 PDF
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1. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study) [J] . DuerrA., HuangY., BuchbinderS., The Journal of Infectious Diseases . 2012,第2期

机译：长期随访证实了重组腺病毒HIV疫苗的随机试验中参与者在早期疫苗中增加了HIV感染的风险，并证明了随着时间的推移效果逐渐减弱（步骤研究）
2. Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study) [J] . Ann Duerr1 Yunda Huang1 Susan Buchbinder2 Robert W. Coombs3 Jorge Sanchez4 Carlos del Rio5 Martin Casapia6 Steven Santiago7 Peter Gilbert1 Lawrence Corey1 Michael N. Robertson8 and for the Step/HVTN 504 Study Team Journal of Infectious Diseases . 2012,第2期

机译：长期随访证实了重组腺病毒HIV疫苗的随机试验中参与者的早期HIV感染风险增加，并随着时间的流逝逐渐减弱。
3. Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines [J] . Koff Wayne C., Russell Nina D., Walport Mark, Vaccine . 2013,第Suppla2期

机译：加速安全有效的艾滋病毒疫苗的开发：疫苗十年的艾滋病毒疫苗案例研究
4. HIV Vaccine Development [C] . M. I. Johnston Conference on Orphan Vaccines : Bridging the Gap . 2002

机译：艾滋病毒疫苗开发
5. Evaluation of different SIV plasmid DNA vaccines: A model for HIV vaccine development. [D] . Busch, Marc Gregory. 2004

机译：不同SIV质粒DNA疫苗的评估：HIV疫苗开发的模型。
6. Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study) [O] . Ann Duerr, Yunda Huang, Susan Buchbinder, -1

机译：长期随访证实了重组腺病毒HIV疫苗的随机试验中参与者的早期HIV感染风险增加并随着时间的流逝逐渐减弱。
7. No acquisition: A new ambition for HIV vaccine development? [O] . Samir K Lakhashe, Guido Silvestri, Ruth M Ruprecht 2011

机译：没有收购：艾滋病毒疫苗开发的新野心？

No Acquisition: a New Ambition for HIV Vaccine Development?

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