首页> 美国卫生研究院文献>Journal of Digital Imaging >Variability of Semiautomated Lung Nodule Volumetry on Ultralow-Dose CT: Comparison with Nodule Volumetry on Standard-Dose CT
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Variability of Semiautomated Lung Nodule Volumetry on Ultralow-Dose CT: Comparison with Nodule Volumetry on Standard-Dose CT

机译:超低剂量CT半自动肺结节容积的可变性:与标准剂量CT结节容积的比较

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摘要

The study investigates the effect of a substantial dose reduction on the variability of lung nodule volume measurements by assessing and comparing nodule volumes using a dedicated semiautomated segmentation software on ultralow-dose computed tomography (ULD-CT) and standard-dose computed tomography (SD-CT) data. In 20 patients, thin-slice chest CT datasets (1 mm slice thickness; 20% reconstruction overlap) were acquired at ultralow-dose (120 kV, 5 mAs) and at standard-dose (120 kV, 75 mAs), respectively, and analyzed using the segmentation software OncoTREAT (MeVis, Bremen, Germany; version 1.3). Interobserver variability of volume measurements of 202 solid pulmonary nodules (mean diameter 11 mm, range 3.2–44.5 mm) was calculated for SD-CT and ULD-CT. With respect to interobserver variability, the 95% confidence interval for the relative differences in nodule volume in the intrascan analysis was measured with −9.7% to 8.3% (mean difference −0.7%) for SD-CT and with −12.6% to 12.4% (mean difference −0.2%) for ULD-CT. In the interscan analysis, the 95% confidence intervals for the differences in nodule volume ranged with −25.1% to −23.4% and 26.2% to 28.9% (mean difference 1.4% to 2.1%) dependent on the combination of readers and scans. Intrascan interobserver variability of volume measurements was comparable for ULD-CT and SD-CT data. The calculated variability of volume measurements in the interscan analysis was similar to the data reported in the literature for CT data acquired with equal radiation dose. Thus, the evaluated segmentation software provides nodule volumetry that appears to be independent of the dose level with which the CT source dataset is acquired.
机译:该研究通过使用专用的半自动分割软件对超低剂量计算机断层扫描(ULD-CT)和标准剂量计算机断层扫描(SD-)进行评估和比较结节体积,研究了大幅减少剂量对肺结节体积测量变异性的影响CT)数据。在20例患者中,分别以超低剂量(120 kV,5 mAs)和标准剂量(120 kV,75 mAs)采集了薄层胸部CT数据集(1毫米切片厚度; 20%重建重叠),并且使用细分软件OncoTREAT(MeVis,德国不莱梅; 1.3版)进行分析。对于SD-CT和ULD-CT,计算了202个实体肺结节(平均直径11毫米,范围3.2-44.5毫米)的观察者之间的体积测量差异。关于观察者间的变异性,在扫描内分析中,结节体积相对差异的95%置信区间被测量为SD-CT为-9.7%至8.3%(平均差异为-0.7%),而-12.6%至12.4% (均值差-0.2%)用于ULD-CT。在扫描间分析中,结节体积差异的95%置信区间为-25.1%至-23.4%和26.2%至28.9%(平均差异1.4%至2.1%),具体取决于读取器和扫描的组合。扫描内观察者间体积测量的可变性与ULD-CT和SD-CT数据相当。在扫描间分析中计算的体积测量变异性与文献中报道的以相同辐射剂量获取的CT数据相似。因此,评估的分割软件提供的结节容积似乎与获取CT源数据集的剂量水平无关。

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