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Diminished AMPK signaling response to fasting in Thioredoxin-interacting Protein Knockout Mice

机译:减少了AMPK信号传导反应以捕获脂素 - 相互作用蛋白敲除小鼠的禁食

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摘要

Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of AMPK and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip.

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