Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.

Andres AM; Ratliff EP; Sachithanantham S; Hui ST

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Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.

机译：在与硫氧还蛋白相互作用的蛋白质敲除小鼠中，空腹的AMPK信号传导反应减弱。

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Thioredoxin-interacting protein (Txnip) knockout (TKO) mice exhibit impaired response to fasting. Herein, we showed that activation of adenine monophosphate-activated protein kinase and cellular AMP levels were diminished in the heart and soleus muscle but not in gastrocnemius muscle of fasting TKO mice. Similarly, glycogen content in fasted TKO mice was increased in oxidative muscles but was not different in glycolytic muscles. These data suggest Txnip deficiency has a higher impact on oxidative muscle than glycolytic muscles and provide new insights into the metabolic role of Txnip.

机译：硫氧还蛋白相互作用蛋白（Txnip）敲除（TKO）小鼠对禁食的反应受损。在这里，我们显示了在空腹TKO小鼠的心脏和比目鱼肌中腺嘌呤单磷酸激活的蛋白激酶的激活和细胞AMP的水平降低了，而腓肠肌中却没有。同样，禁食的TKO小鼠中的糖原含量在氧化性肌肉中增加，但在糖酵解性肌肉中没有变化。这些数据表明，Txnip缺乏症对氧化性肌肉的影响比糖酵解性肌肉高，并为Txnip的代谢作用提供了新见解。

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《FEBS letters.》 |2011年第8期|共8页
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Andres AM; Ratliff EP; Sachithanantham S; Hui ST;
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1. Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice. [J] . Andres AM, Ratliff EP, Sachithanantham S, FEBS letters. . 2011,第8期

机译：在与硫氧还蛋白相互作用的蛋白质敲除小鼠中，空腹的AMPK信号传导反应减弱。
2. Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice. [J] . Murali SG, Liu X, Nelson DW, American Journal of Physiology . 2007,第6期

机译：在IGF结合蛋白-5基因敲除小鼠中，外源性IGF-1的肠营养作用并未减弱。
3. Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice. [J] . Murali SG, Liu X, Nelson DW, American Journal of Physiology . 2007,第6期

机译：在IGF结合蛋白-5基因敲除小鼠中，外源性IGF-1的肠营养作用并未减弱。
4. New insights into Doppel neurotoxicity using cerebellar organotypic cultures from prion protein-deficient mice. [C] . Dole S, Heitz S, Bombarde G, International PRION Congress . 2010

机译：朊病毒蛋白质缺陷小鼠小脑有机型培养物对Doppel神经毒性的新见解。
5. Metabolic role of thioredoxin-interacting protein in facilitating the fasting response. [D] . Andres, Allen Mariano. 2009

机译：硫氧还蛋白相互作用蛋白在促进空腹反应中的代谢作用。
6. Diminished AMPK signaling response to fasting in Thioredoxin-interacting Protein Knockout Mice [O] . Allen M. Andres, Eric P. Ratliff, Sowbarnika Sachithanantham, -1

机译：减少了AMPK信号传导反应以捕获脂素 - 相互作用蛋白敲除小鼠的禁食
7. Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice [O] . Andres Allen M., Ratliff Eric P., Sachithanantham Sowbarnika, 2011

机译：在与硫氧还蛋白相互作用的蛋白敲除小鼠中对空腹的AMPK信号传导反应减弱

Diminished AMPK signaling response to fasting in thioredoxin-interacting protein knockout mice.

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