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Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV

机译：豚鼠巨细胞病毒Gp84是人巨细胞病毒的功能同源物（HCmV）UL84基因可以在嵌合HCmV补充为UL84的损失

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The guinea pig cytomegalovirus (GPCMV) co-linear gene and potential functional homolog of HCMV UL84 (GP84) was investigated. The GP84 gene had delayed early transcription kinetics and transient expression studies of GP84 protein (pGP84) demonstrated that it targeted the nucleus and co-localized with the viral DNA polymerase accessory protein as described for HCMV pUL84. Additionally, pGP84 exhibited a transdominant inhibitory effect on viral growth as described for HCMV. The inhibitory domain could be localized to a minimal peptide sequence of 99 aa. Knockout of GP84 generated virus with greatly impaired growth kinetics. Lastly, the GP84 ORF was capable of complementing for the loss of the UL84 coding sequence in a chimeric HCMV. Based on this research and previous studies we conclude that GPCMV is similar to HCMV by encoding single copy co-linear functional homologs of HCMV UL82 (pp71), UL83 (pp65) and UL84 genes.

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A. McGregor; K.Y. Choi; M.R. Schleiss;
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年(卷),期 -1(410),1
年度 -1
页码 76–87
总页数 25
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1. Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV. [J] . McGregor A, Choi KY, Schleiss MR Virology . 2011,第1期

机译：豚鼠巨细胞病毒GP84是人类巨细胞病毒（HCMV）UL84基因的功能同源物，可以补充嵌合HCMV中UL84的丢失。
2. Polyfunctional Analysis of Human Cytomegalovirus (HCMV)-Specific CD4(+) and CD8(+) Memory T-Cells in HCMV-Seropositive Healthy Subjects Following Different Stimuli [J] . Gabanti Elisa, Bruno Francesca, Fornara Chiara, Journal of Clinical Immunology . 2014,第8期

机译：人类巨细胞病毒（HCMV）特异性CD4（+）和CD8（+）记忆T细胞在不同刺激后HCMV血清阳性健康受试者中的多功能分析
3. Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication. [J] . Kagele D, Gao Y, Smallenburg K Virology . 2009,第1期

机译：HCMV UL84与oriLyt中C / EBPalpha转录因子结合位点的相互作用对于裂解DNA复制至关重要。
4. Differential compartmentalization of functional and structural proteins of human cytomegalovirus in nuclei and nuclear matrices of infected human embryo fibroblasts [C] . M.C. Arcangeletti, F. De Conto, F. Ferraglia, European Congress of Virology . 2004

机译：感染人胚胎成纤维细胞核和核基质中人巨细胞病毒功能和结构蛋白的差分分界化
5. Human cytomegalovirus infection in human umbilical vein endothelial cells; human cytomegalovirus infection in hematopoietic progenitor cells: Model of HCMV latency [D] . Zhuravskya, Tatiana. 1997

机译：人脐静脉内皮细胞中的人巨细胞病毒感染；造血祖细胞中人类巨细胞病毒感染：HCMV潜伏期模型
6. Internal Deletions of IE2 86 and Loss of the Late IE2 60 and IE2 40 Proteins Encoded by Human Cytomegalovirus Affect the Levels of UL84 Protein but Not the Amount of UL84 mRNA or the Loading and Distribution of the mRNA on Polysomes [O] . Rebecca L. Sanders, Christia J. Del Rosario, Elizabeth A. White, 2008

机译：IE2 86的内部缺失和人巨细胞病毒编码的IE2 60和IE2 40晚期蛋白的丢失影响UL84蛋白的水平但不影响UL84 mRNA的量或mRNA在多核糖体上的负载和分布
7. Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV [O] . McGregor A., Choi K.Y., Schleiss M.R. 2011

机译：豚鼠巨细胞病毒GP84是人类巨细胞病毒（HCMV）UL84基因的功能同源物，可以补充嵌合HCMV中UL84的丢失

Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV

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