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首页> 美国卫生研究院文献>other >Novel role of specific Tudor domains in Tudor - Aubergine protein complex assembly and distribution during Drosophila oogenesis
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Novel role of specific Tudor domains in Tudor - Aubergine protein complex assembly and distribution during Drosophila oogenesis

机译：特定铎冠域在铎王格蛋白复杂组装和果蝇苗咽分布中的小说作用

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Germ cells give rise to the next generation and contain ribonucleoprotein particles, germ granules. In these granules, Piwi protein Aubergine has been shown to interact with Tudor protein in Drosophila. Tudor protein has eleven Tudor domains and it has been unclear to what extent all these domains are involved in the interaction with Aubergine. Here we present direct biochemical evidence that Tudor - Aubergine interaction surface is composed of different Tudor domains including those that have not been previously implicated in Aubergine recognition. Furthermore, we show that specific single Tudor domains determine localization of Tudor complex to different sites in ovarian germ cells. Our data suggest that multiple Tudor domains of germline proteins from various species are redundantly used for interaction with the same protein partner during germline development.

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