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首页> 美国卫生研究院文献>other >Disruption of Performance in the 5-Choice Serial Reaction Time Task Induced by Administration of NMDA Receptor Antagonists: Relevance to Cognitive Dysfunction in Schizophrenia
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Disruption of Performance in the 5-Choice Serial Reaction Time Task Induced by Administration of NMDA Receptor Antagonists: Relevance to Cognitive Dysfunction in Schizophrenia

机译：精神分裂症相关性认知功能障碍：在5选择串行反应时间任务诱发NmDa受体拮抗剂的管理绩效的破坏

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Schizophrenia patients suffer from cognitive impairments that are not satisfactorily treated by currently available medications. Cognitive dysfunction in schizophrenia encompasses deficits in several cognitive modalities that can be differentially responsive to different medications and are likely to be mediated by different neurobiological substrates. Translational animal models of cognitive deficits with relevance to schizophrenia are critical for gaining insights into the mechanisms underlying these impairments and developing more effective treatments. The 5-choice serial reaction time task (5-CSRTT) is a cognitive task used in rodents that allows simultaneous assessment of several cognitive modalities, including attention, response inhibition, cognitive flexibility, and processing speed. Administration of N-methyl-D-aspartate (NMDA) glutamate receptor antagonists disrupts multiple 5-CSRTT performance measures in a way that mirrors various cognitive deficits exhibited by schizophrenia patients. Some of these disruptions are partially attenuated by antipsychotic medications that exhibit partial effectiveness on cognitive dysfunction in schizophrenia, suggesting that the model has predictive validity. Examination of the effects of pharmacological manipulations on 5-CSRTT performance disruptions induced by NMDA antagonists have implicated a range of brain regions, neurotransmitter systems, and specific receptor subtypes in schizophrenia-like impairment of different cognitive modalities. Thus, disruption of 5-CSRTT performance by NMDA antagonists represents a valuable tool for exploring the neurobiological bases of cognitive dysfunction in schizophrenia.

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    Nurith Amitai; Athina Markou;

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  • 年(卷),期 -1(68),1
  • 年度 -1
  • 页码 5–16
  • 总页数 25
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