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首页> 外文期刊>Behavioural pharmacology >Effects of biasing the location of stimulus presentation, and the muscarinic cholinergic receptor antagonist scopolamine, on performance of a 5-choice serial reaction time attention task in rats.
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Effects of biasing the location of stimulus presentation, and the muscarinic cholinergic receptor antagonist scopolamine, on performance of a 5-choice serial reaction time attention task in rats.

机译：偏向刺激表现的位置，和毒蕈碱胆碱能受体拮抗剂东amine碱，对大鼠的5选择系列反应时间注意任务的性能的影响。

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摘要

A major purpose of the present studies was to determine the effects of varying the relative frequency, or bias, of stimulus presentation at different locations in a five-choice serial reaction time attention task. Training sessions were conducted in which the stimulus duration was held constant at 2 s and, initially, stimuli were presented with equal probability above each of the levers. During testing sessions, however, stimulus duration was either 0.2 or 2 s, and the frequency of presentation was varied among no bias, a middle bias, a left bias or a right bias condition. The training conditions were then changed such that the frequency of presentation was always a left bias, and test sessions were again conducted with no, middle, left or right bias. In the presence of the 0.2-s, but not the 2.0-s, stimulus, the percentage of correct responding on each of the choice levers during test sessions varied directly with the bias conditions in that the percentage of correct responding was highest at the mostfrequently presented location and lowest at the least frequently presented location. In addition, scopolamine, but not metscopolamine, increased omissions while also increasing anticipatory responses in rats trained under left-bias conditions and tested under right-bias conditions. The present findings suggest that varying the frequency of stimulus location can provide additional measures of attention in the five-choice serial reaction time task.
机译：本研究的主要目的是确定在五选择系列反应时间关注任务中，在不同位置改变刺激呈现的相对频率或偏差的影响。进行了培训课程，其中刺激持续时间保持恒定在2 s，最初，在每个杠杆上方均以相同的概率呈现刺激。然而，在测试过程中，刺激持续时间为0.2或2 s，并且出现的频率在无偏见，中偏见，左偏见或右偏情况之间变化。然后改变训练条件，使出现的频率始终是左偏，然后再次进行测试，无，中，左或右偏。在存在0.2秒而不是2.0秒刺激的情况下，测试期间每个选择杆上正确响应的百分比会随偏差条件而直接变化，因为正确响应的百分比最高呈现位置，并在最不频繁呈现的位置显示最低的位置。另外，在左偏条件下训练并在右偏条件下测试的大鼠中，东pol碱而不是美白sco增加了遗漏，同时还增加了预期反应。目前的发现表明，改变刺激位置的频率可以在五选择序列反应时间任务中提供额外的注意措施。

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