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首页> 美国卫生研究院文献>other >The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats’ performance in the 5-choice serial reaction time task.
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The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats’ performance in the 5-choice serial reaction time task.

机译：mGluR5拮抗剂MPEP和mGluR2 / 3拮抗剂LY341495对大鼠在5选择序列反应时间任务中的表现的影响。

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摘要

Schizophrenia is characterized by attentional deficits possibly associated with glutamate dysfunction. The role of postsynaptic metabotropic glutamate 5 (mGluR5) or presynaptic inhibitory mGluR2/3 on attention is currently unknown. We investigated the effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist on attention in the 5-choice serial reaction time task (5CSRTT), as well as on food intake to evaluate their effects on food motivation. The effects of pre-feeding and the muscle relaxant curare were examined to characterize the effects of alterations in motivation or the ability to perform the task, respectively. MPEP had no effect on accuracy but overall decreased performance in the 5CSRTT, including decreased speed of responding and decreased premature responses. had no significant effect on rats’ performance in the 5CSRTT. decreased food intake in the home cage to a greater extent than MPEP. Curare decreased the speed of correct responding, reflecting motor impairment. Free feeding decreased overall performance, number of trials completed and number of head entries into the feeder, reflecting decreased motivation to perform the task. Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT.
机译：精神分裂症的特征在于注意力缺陷，可能与谷氨酸功能障碍有关。目前尚不清楚突触后代谢型谷氨酸5（mGluR5）或突触前抑制性mGluR2 / 3的作用。我们调查了mGluR5拮抗剂MPEP和mGluR2 / 3拮抗剂在5选择序列反应时间任务（5CSRTT）中的注意力以及对食物摄入的影响，以评估它们对食物动机的影响。分别检查了预喂食和肌肉松弛药的作用，以表征动机改变或执行任务的能力的影响。 MPEP对准确性没有影响，但是5CSRTT的总体性能下降，包括响应速度下降和过早响应下降。对5CSRTT大鼠的表现没有明显影响。与MPEP相比，减少了笼中食物的摄入量。 Curare降低了正确响应的速度，反映了运动障碍。自由进食会降低总体性能，完成的试验次数以及进入进料器的人数，这反映出执行任务的动力降低。因此，对mGluR5的阻断而不是mGluR2 / 3的阻断降低了总体响应，而不会影响5CSRTT的准确性。

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