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Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: confounding role of the inhibitory FcγRIIb

机译：定义Fc受体样B（FCR1b）缺陷小鼠的免疫表型：抑制性FcγRIIB的混杂作用

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Fc receptor-like A (FCRLA) and FCRLB have homology to the transmembrane FCRL family members (FCRL1–6) and to the conventional receptors for the Fc portion of immunoglobulin, but uniquely are cytosolic proteins expressed in B cells. Here we describe the phenotype of Fcrlb gene targeted mice. B cell development and in vitro responses are normal; however, antibody responses to a T-dependent antigen are elevated. The gene encoding the inhibitory FcγRIIb is located nearby Fcrlb. Although Fcrlb gene targeting had no effect on the function or basal expression of FcγRIIb, its expression was reduced following activation. This abnormal regulation was due to co-inheritance of Fcgr2b and the mutant Fcrlb allele from the 129 ES cells. A promoter polymorphism in the 129/Sv Fcgr2b allele results in diminished upregulation of FcγRIIb following B cell activation. Thus, we speculate that the enhanced antibody response seen in the FCRLB-deficient mice may be due to the Fcgr2b promoter.

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