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首页> 外文期刊>Cellular immunology >Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcgammaRIIb.
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Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcgammaRIIb.

机译：定义Fc受体样B（FCRLB）缺陷小鼠的免疫表型：抑制性FcgammaRIIb的混杂作用。

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Fc receptor-like A (FCRLA) and FCRLB have homology to the transmembrane FCRL family members (FCRL 1-6) and to the conventional receptors for the Fc portion of immunoglobulin, but uniquely are cytosolic proteins expressed in B cells. Here we describe the phenotype of Fcrlb-gene targeted mice. B cell development and in vitro responses are normal; however, antibody responses to a T-dependent antigen are elevated. The gene encoding the inhibitory FcgammaRIIb is located nearby Fcrlb. Although Fcrlb-gene targeting had no effect on the function or basal expression of FcgammaRIIb, its expression was reduced following activation. This abnormal regulation was due to co-inheritance of Fcgr2b and the mutant Fcrlb allele from the 129 ES cells. A promoter polymorphism in the 129/Sv Fcgr2b allele results in diminished upregulation of FcgammaRIIb following B cell activation. Thus, we speculate that the enhanced antibody response seen in the FCRLB-deficient mice may be due to the Fcgr2b promoter.
机译：Fc受体样A（FCRLA）和FCRLB与跨膜FCRL家族成员（FCRL 1-6）和免疫球蛋白Fc部分的常规受体具有同源性，但独特的是B细胞中表达的胞质蛋白。在这里，我们描述了Fcrlb基因靶向小鼠的表型。 B细胞发育和体外反应正常;然而，对T依赖性抗原的抗体应答升高。编码抑制性FcgammaRIIb的基因位于Fcrlb附近。尽管Fcrlb基因靶向对FcgammaRIIb的功能或基础表达没有影响，但其表达在激活后降低。这种异常调节是由于来自129 ES细胞的Fcgr2b和突变型Fcrlb等位基因的共同遗传。 129 / Sv Fcgr2b等位基因中的启动子多态性导致B细胞激活后FcgammaRIIb的上调减少。因此，我们推测在FCRLB缺陷小鼠中看到的抗体应答增强可能是由于Fcgr2b启动子。

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