RELT induces cellular death in HEK 293 epithelial cells

机译：RELT诱导细胞死亡HEK 293个上皮细胞

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RELT is a recently identified Tumor Necrosis Factor Receptor that posesses two homologues in humans named RELL1 and RELL2. We investigated whether RELT and its homologues could induce cellular death when transiently transfected into HEK 293 epithelial cells. Transfection of RELT family members into HEK 293 epithelial cells induced cell death characterized by rounding and lifting of cells accompanied by DNA fragmentation, characteristics that are consistent with the activation of an apoptotic pathway. Overexpression of RELT in COS-7 cells resulted in cell rounding and lifting without DNA fragmentation, suggesting that the effects of RELT signaling may vary among different cell types. In summary, we report that overexpression of RELT or its homologues RELL1 and RELL2 in HEK 293 epithelial cells results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway.

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John K. Cusick; Andrea Mustian; Kate Goldberg; Mary E. Reyland;
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年(卷),期 -1(261),1
年度 -1
页码 1–8
总页数 19
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专利

1. RELT induces cellular death in HEK 293 epithelial cells. [J] . Cusick JK, Mustian A, Goldberg K, Cellular immunology . 2010,第1期

机译：RELT诱导HEK 293上皮细胞死亡。
2. Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms. [J] . Ashokkumar B, Vaziri ND, Said HM American Journal of Physiology . 2006,第4期

机译：人源性肾上皮（HEK-293）细胞摄取硫胺素：细胞和分子机制。
3. Cold atmospheric-pressure nitrogen plasma induces the production of reactive nitrogen species and cell death by increasing intracellular calcium in HEK293T cells [J] . Iuchi Katsuya, Morisada Yukina, Yoshino Yuri, Archives of Biochemistry and Biophysics . 2018,第期

机译：冷气氛 - 压力氮等离子体通过增加HEK293T细胞的细胞内钙产生反应性氮物质和细胞死亡
4. Effect of Formaldehyde on Cellular Proliferation of HEK293 cells [C] . Xu Qian, He Hujun, Yang Guangtao, The 1st International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2007) . 2007

机译：甲醛对HEK293细胞增殖的影响
5. Cellular and molecular responses of epithelial cells to distinct forms of cell death. [D] . Lubkov, Veronica. 2013

机译：上皮细胞对细胞死亡的不同形式的细胞和分子反应。
6. Furosine induces DNA damage and cell death in selected human cell lines: a strong toxicant to kidney Hek-293 cells [O] . Yasmeen Saeed, J. Q. Wang, N. Zheng 2017

机译：呋喃肾上腺素在选定的人类细胞系中诱导DNA损伤和细胞死亡：对肾脏Hek-293细胞的强毒剂
7. RELT induces cellular death in HEK 293 epithelial cells [O] . John K. Cusick, Andrea Mustian, Kate Goldberg, 2010

机译：Relt在HEK 293上皮细胞中诱导细胞死亡
8. Sulfur Mustard Induces Apoptosis in Cultured Normal Human Airway Epithelial Cells: Evidence of a Dominant Caspase-8-Mediated Pathway and Differential Cellular Responses [R] . Ray, R., Keyser, B., Benton, B., 2008

机译：硫芥诱导培养的正常人呼吸道上皮细胞凋亡：Caspase-8介导的主要途径和差异细胞反应的证据

RELT induces cellular death in HEK 293 epithelial cells

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