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Monitoring the fluidized bed granulation process based onS-statistic analysis of a pressure time series

机译：基于压力时间序列的统计分析监控流化床造粒过程

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摘要

Pressure fluctuation measurements collected during the fluidized bed granulation of pharmaceutical granule have been analyzed using the attractor comparison technique denoted as theS-statistic. Divergence of the bed state from the reference during granulation is followed by a return to a condition statistically similar to the original state of the dry fluidized ingredients on drying. This suggests insensitivity of theS-statistic technique to the changes in particle size distribution occurring during the granulation process. Consequently, the monitoring of pressure fluctuations alone may provide an easily implemented technique for the tracking of granule moisture and process end-point determination.

机译：使用表示为S统计量的吸引子比较技术分析了药物颗粒流化床制粒过程中收集的压力波动测量值。造粒过程中床状态与参考值不同，然后返回到统计上类似于干燥时干燥流态化成分的原始状态的状态。这表明S统计技术对造粒过程中发生的粒度分布变化不敏感。因此，单独监测压力波动可为跟踪颗粒水分和确定工艺终点提供一种易于实施的技术。

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期刊名称 AAPS PharmSciTech
作者
Gareth Chaplin; Todd Pugsley; Conrad Winters;
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作者单位

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年(卷),期 2005(6),2
年度 2005
页码 E198–E201
总页数 4
原文格式 PDF
正文语种
中图分类药学;
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专利

1. Comparison of three different methodologies of pressure signal processing to monitor fluidized-bed dryers/granulators [J] . Lilian de Martin, Kaspar van den Dries, J. Ruud van Ommen Chemical engineering journal . 2011,第1期

机译：比较三种不同的压力信号处理方法来监控流化床干燥机/制粒机
2. Real-Time Monitoring of Gas-Solid Fluidized-Bed Granulation and Coating Process: Evolution of Particle Size, Fluidization Regime Transitions, and Psychometric Parameters [J] . da Silva C. A. M., Taranto O. P. Drying technology: An International Journal . 2015,第13a16期

机译：气固流化床造粒和包衣过程的实时监控：粒度变化，流态化转变和心理参数
3. Real-time monitoring and fault detection of pulsed-spray fluid-bed granulation using near-infrared spectroscopy and multivariate process trajectories [J] . Jie Zhao, Wenlong Li, Haibin Qu, 颗粒学报（英文版） . 2020,第006期

机译：使用近红外光谱和多变量工艺轨迹使用脉冲喷涂流体床造粒的实时监测和故障检测
4. Chaotic Time Series Analysis of Pressure Fluctuation Signals in a Fluidized Bed Evaporator of Natural Circulation [C] . Yan Liu, Shao-feng Zhang Third International Measuring Technology and Mechatronics Automation . 2011

机译：自然循环流化床蒸发器压力波动信号的混沌时间序列分析
5. Dynamics and flow non-uniformity study in circulating fluidized beds of different design features using time series analysis. [D] . Manyele, Samwel Victor. 2001

机译：使用时间序列分析研究不同设计特征的循环流化床中的动力学和流动非均匀性。
6. Monitoring Granulation Rate Processes Using Three PAT Tools in a Pilot-Scale Fluidized Bed [O] . Ai Tee Tok, Xueping Goh, Wai Kiong Ng, 2008

机译：使用三个PAT工具在中试流化床中监测制粒速率过程
7. Monitoring the fluidized bed granulation process based onS-statistic analysis of a pressure time series [O] . Chaplin, Gareth, Pugsley, Todd, Winters, Conrad 2005

机译：基于压力时间序列的S统计分析监测流化床造粒过程
8. Characterization of the fluidization behavior of different solid types based on chaotic time series analysis of pressure signals. [R] . Daw, C. S., Nguyen, K., Skrzycke, D. P. 1993

机译：基于压力信号的混沌时间序列分析表征不同固体类型的流化行为。

Monitoring the fluidized bed granulation process based onS-statistic analysis of a pressure time series

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