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Error detection failures in schizophrenia: ERPs and fMRI

机译：精神分裂症中的错误检测失败：ERPS和FMRI

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Self-monitoring of actions, critical for guiding goal-directed behavior, is deficient in schizophrenia. Defective error-monitoring may reflect more general self-monitoring deficiencies. The error-related negativity (ERN) component of the event-related potential (ERP) is smaller in patients with schizophrenia, and anterior cingulate cortex (ACC) and dorsolateral pre-frontal cortex (DLPFC), both critical for error detection, are less responsive to errors in patients with schizophrenia, as revealed with functional magnetic resonance imaging (fMRI).ERP and fMRI data were collected while 11 patients with schizophrenia and 10 healthy controls performed a Go-NoGo task requiring a button press to Xs (p=.88) while withholding responses to Ks (p=.12). We measured the ERN and ACC and DLPFC activations to false alarms.The task elicited a robust ERN and modest activations in ACC and DLPFC to false alarms. As expected, ERN was larger in controls than patients. However, ACC and DLPFC activations were not greater in controls than patients. Surprisingly, DLPFC was more activated by errors in patients than controls.ERPs may be superior for assessing error processing because (1) ERNs can be measured precisely without needing to control for the multiple comparisons of fMRI, and (2) ERPs have the temporal precision to detect transient activity necessary for error detection and on-the-fly behavioral adjustments.

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