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首页> 美国卫生研究院文献>Journal of Clinical Microbiology >Cefoperazone disk diffusion susceptibility test: confirmation of the tentative interpretive criteria Pseudomonas aeruginosa cross-resistance and determination of quality control performance limits.
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Cefoperazone disk diffusion susceptibility test: confirmation of the tentative interpretive criteria Pseudomonas aeruginosa cross-resistance and determination of quality control performance limits.

机译：头孢哌酮圆盘扩散药敏试验：确认试验性解释标准铜绿假单胞菌交叉耐药性和确定质量控制性能极限。

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Cefoperazone disk diffusion test and minimum inhibitory concentration comparison studies were performed on 421 recent bacterial isolates, using 30- and 75-micrograms commercially prepared disks. Acceptable correlation coefficients (-0.82 to -0.86) and very major (false-susceptible) interpretive error rates (less than 1%) were obtained with both disk concentrations. The interpretive criteria for both disks were identical. Using the preferred 75-micrograms disk, the Thornsberry et al. criteria (J. Clin. Microbiol. 15:769-776, 1982) of greater than or equal to 18 mm = susceptible (less than or equal to 32 micrograms/ml) and less than or equal to 14 mm = resistant (greater than 64 micrograms/ml) resulted in only 5.5% of strains having indeterminate-range zone diameters; the 30-micrograms disk had 6.9% of strains with indeterminate zone diameters. The 75-micrograms disk, excluding the testing of enterococci, minimized the very major and other interpretive errors to less than 5%. Larger zone diameters will contribute few technical problems with either disk concentration. Data from 1,320 zone diameters submitted for each quality control strain indicated no significant (P greater than 0.05) difference between disks made by the three major manufacturers, and consistent results were obtained within each laboratory with numerous lots of Mueller-Hinton agar (except for one manufacturer). Individual daily test and accuracy quality control ranges were calculated from clinical investigator laboratory data at 16 hospitals based on mean zone sizes and from an additional 8 laboratories with both mean and median calculations. The quality control data were nearly identical, and ranges calculated by the two methods were very similar. Susceptibility tests of Pseudomonas aeruginosa indicate that the cefoperazone disk or minimum inhibitory concentration test would accurately predict P. aeruginosa susceptibility test results for other pseudomonas-active cephalosporins (cefsulodin and ceftazidime), thus producing no very major interpretive errors.
机译：头孢哌酮圆盘扩散试验和最小抑菌浓度比较研究是使用30毫克和75毫克商业制备的圆盘对421种近期分离的细菌进行的。两种圆盘浓度都获得了可接受的相关系数（-0.82至-0.86）和非常大的（错误敏感性）解释错误率（小于1％）。两个磁盘的解释标准相同。使用首选的75微克圆盘，Thornsberry等人。大于或等于18毫米的标准（J. Clin。Microbiol。15：769-776，1982）=易感（小于或等于32微克/毫升）且小于或等于14毫米=抗药性（大于64微克/毫升）仅产生5.5％的菌株具有不确定范围的区域直径; 30毫克的圆盘有6.9％的应变带不确定的区域直径。 75微克磁盘（不包括肠球菌测试）将非常大的解释错误和其他解释错误的发生率降至了5％以下。较大的区域直径将不会对磁盘​​集中产生任何技术问题。针对每种质量控制菌株提交的1,320个区域直径的数据表明，三个主要制造商生产的圆盘之间没有显着差异（P大于0.05），并且在每个实验室中使用大量Mueller-Hinton琼脂获得了一致的结果（除了一个制造商）。根据平均区域大小，从16家医院的临床研究人员实验室数据中，以及从另外8个实验室进行平均值和中位数计算，计算出每日的日常测试和准确性质量控制范围。质量控制数据几乎相同，并且两种方法计算的范围非常相似。铜绿假单胞菌的药敏试验表明，头孢哌酮圆盘或最小抑菌浓度试验可以准确预测其他对铜绿假单胞菌有活性的头孢菌素（头孢磺啶和头孢他啶）的铜绿假单胞菌药敏试验结果，因此不会产生重大的解释错误。

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