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Physical Properties and Biological Activity of Poly(butyl acrylate–styrene) Nanoparticle Emulsions Prepared with Conventional and Polymerizable Surfactants

机译：常规和可聚合表面活性剂制备的聚（丙烯酸丁酯-苯乙烯）纳米粒子乳液的物理性质和生物活性

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Recent efforts in our laboratory have explored the use of polyacrylate nanoparticles in aqueous media as stable emulsions for potential applications in treating drug-resistant bacterial infections. These emulsions are made by emulsion polymerization of acrylated antibiotic compounds in a mixture of butyl acrylate and styrene (7:3 w:w) using sodium dodecyl sulfate (SDS) as a surfactant. Prior work in our group established that the emulsions required purification to remove toxicity associated with extraneous surfactant present in the media. This paper summarizes our investigations of poly(butyl acrylate-styrene) emulsions made using anionic, cationic, zwitterionic, and non-charged (amphiphilic) surfactants, as well as attachable surfactant monomers (surfmers), comparing the cytotoxicity and microbiological activity levels of the emulsion both before and after purification. Our results show that the attachment of a polymerizable surfmer onto the matrix of the nanoparticle neither improves nor diminishes cytotoxic or antibacterial effects of the emulsion, regardless of whether the emulsions are purified or not, and that the optimal properties are associated with the use of the non-ionic surfactants versus those carrying anionic, cationic, or zwitterionic charge. Incorporation of an N-thiolated β-lactam antibacterial agent onto the nanoparticle matrix via covalent attachment endows the emulsion with antibiotic properties against pathogenic bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), without changing the physical properties of the nanoparticles or their emulsions.
机译：我们实验室最近的努力探索了聚丙烯酸酯纳米颗粒在水性介质中作为稳定乳剂的用途，可用于治疗耐药细菌感染。这些乳液是通过使用十二烷基硫酸钠（SDS）作为表面活性剂，在丙烯酸丁酯和苯乙烯（7：3 w：w）的混合物中丙烯酸酯化的抗生素化合物乳液聚合而成的。我们小组的先前工作确定乳液需要纯化以除去与培养基中存在的无关表面活性剂相关的毒性。本文总结了我们对使用阴离子，阳离子，两性离子和不带电（两亲性）表面活性剂以及可附着的表面活性剂单体（表面活性剂）制成的聚（丙烯酸丁酯-苯乙烯）乳液的研究，比较了它们的细胞毒性和微生物活性水平纯化前后的乳液。我们的结果表明，无论乳液是否经过纯化，可聚合表面活性剂在纳米颗粒基质上的附着都不会改善或减弱乳液的细胞毒性或抗菌作用，并且最佳性能与乳液的使用有关。非离子表面活性剂与带有阴离子，阳离子或两性离子电荷的那些。通过共价结合将N-硫醇化的β-内酰胺抗菌剂结合到纳米颗粒基质上，可使乳液具有针对病原细菌（例如耐甲氧西林的金黄色葡萄球菌（MRSA））的抗生素特性，而不会改变纳米颗粒或其乳液的物理特性。

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