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Image-Guided Sentinel Lymph Node Mapping and Nanotechnology-Based Nodal Treatment in Lung Cancer using Invisible Near-Infrared Fluorescent Light

机译:图像引导前哨淋巴结定位和基于纳米技术的基于不可见近红外荧光灯的肺癌淋巴结治疗

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摘要

Current methods for sentinel lymph node (SLN) mapping and nodal treatment in lung cancer remain inadequate for routine clinical use. Here we discuss the potential for using the combination of invisible near-infrared (NIR) fluorescent light and nanotechnology for these applications. NIR fluorescence imaging has recently received significant attention for in vivo imaging applications because of its low tissue autofluorescence, high photon penetration into living tissue, and high signal-to-background ratio. Our large animal in vivo studies have been able to successfully identify sentinel lymph nodes in lung tissue and several clinical studies have examined the use of NIR fluorescence imaging systems for SLN mapping in breast and gastric cancer. Promising new nanoparticle technologies, when combined with NIR fluorescence imaging, offer the potential for image-guided treatment of lymph nodes at high risk for tumor recurrence. This review provides a theoretical and empirical framework for developing the next-generation of diagnostic and therapeutic agents for lung cancer.
机译:肺癌中前哨淋巴结(SLN)定位和淋巴结治疗的当前方法仍不足以用于常规临床应用。在这里,我们讨论了将不可见近红外(NIR)荧光灯和纳米技术结合起来用于这些应用的潜力。近红外荧光成像由于其低的组织自发荧光,高的光子渗透到活组织中以及高的信噪比,最近在体内成像应用中受到了广泛的关注。我们的大型动物体内研究已经能够成功鉴定出肺组织中的前哨淋巴结,并且一些临床研究已经检查了使用NIR荧光成像系统在乳腺癌和胃癌中进行SLN定位的能力。结合NIR荧光成像技术,很有希望的新型纳米颗粒技术可为肿瘤复发高风险的淋巴结提供图像指导治疗的潜力。这篇综述为开发下一代肺癌诊断和治疗剂提供了理论和经验框架。

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