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A Convenient Route to 68GaGa-MAA for Use as a Particulate PET Perfusion Tracer

机译：用作68Ga Ga-MAA的便捷途径用作颗粒PET灌注示踪剂

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摘要

A convenient method is described for compounding [⁶⁸Ga]Ga-MAA (MAA = macroaggregated human serum albumin) with the eluate of a commercially available TiO2-based ⁶⁸Ge/⁶⁸Ga generator. The final [⁶⁸Ga]Ga-MAA product was obtained with an 81.6 ± 5.3% decay-corrected radiochemical yield and a radiochemical purity of 99.8 ± 0.1% (n = 5). Microscopic examination showed the [⁶⁸Ga]Ga-MAA product to remain within the original particle size range. The entire procedure, from generator elution to delivery of the final [⁶⁸Ga]Ga-MAA suspension, could be completed in 25 minutes. Only 4.4 ± 0.9% of the total ⁶⁸Ge breakthrough remaining associated with the final [⁶⁸Ga]Ga-MAA product. The procedure allows reasonably convenient preparation of [⁶⁸Ga]Ga-MAA in a fashion that can be readily adapted to sterile product compounding for human use.

机译：描述了一种方便的方法，可将[^{68 Ga] Ga-MAA（MAA =大量聚集的人血清白蛋白）与市售的基于TiO2的^{68 Ge / < sup> 68 Ga发生器。获得最终的[^{68 Ga] Ga-MAA产品，其经衰变校正的放射化学产率为81.6±5.3％，放射化学纯度为99.8±0.1％（n = 5）。显微镜检查显示[^{68 Ga] Ga-MAA产品保持在原始粒径范围内。从发生器洗脱到最终[^{68 Ga] Ga-MAA悬浮液的输送，整个过程都可以在25分钟内完成。 [sup> 68 Ga的最终突破中，剩余的^{68 Ge总数中只有4.4±0.9％。该程序允许以合理的方式方便地制备[^{68 Ga] Ga-MAA，该方式可以容易地适应于供人类使用的无菌产品复合。}}}}}}}

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期刊名称 other
作者
Carla J. Mathias; Mark A. Green;
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年(卷),期 -1(66),12
年度 -1
页码 1910–1912
总页数 5
原文格式 PDF
正文语种
中图分类
关键词
Gallium-68 Macroaggregated Human Serum Albumin (MAA) PET Perfusion;

机译：镓68;人血总蛋白（MAA）;PET;灌注;

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专利

1. A convenient route to (68Ga)Ga-MAA for use as a particulate PET perfusion tracer. [J] . Mathias CJ, Green MA Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2008,第12期

机译：通往（68Ga）Ga-MAA的便捷途径，用作颗粒PET灌注示踪剂。
2. A convenient route to (68Ga)Ga-MAA for use as a particulate PET perfusion tracer. [J] . Mathias CJ, Green MA Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2008,第12期

机译：通往（68Ga）Ga-MAA的便捷途径，用作颗粒PET灌注示踪剂。
3. The ~(nat)Br(p,x) ~(73,75)Se nuclear processes: a convenient route for the production of radioselenium tracers relevant to amino acid labelling [J] . Michael Faβbender, Dawid de Villiers, Meiring Nortier, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2001,第6期

机译：〜（nat）Br（p，x）〜（73,75）Se核过程：生产与氨基酸标记有关的放射性硒示踪剂的便捷途径
4. Development of a 4D digital phantom for tracer kinetic modeling and analysis of dynamic perfusion PET and SPECT simulation studies [C] . Fung George S. K., Higuchi Takahiro, Park Min Jae, Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2011 IEEE . 2011

机译：用于示踪剂动力学建模和动态灌注PET和SPECT模拟研究分析的4D数字体模的开发
5. Development and Simulation-based Validation of Practical Methods for Estimating Whole-heart Blood-flow Using Perfusion Tracers and a Dual Camera Spect System [D] . Hossain, Jakir. 2017

机译：开发和基于仿真的使用灌注示踪剂和双摄像头观测系统估算全心血流量的实用方法的验证
6. Moving into the next era of PET myocardial perfusion imaging: introduction of novel 18F-labeled tracers [O] . Rudolf A. Werner, Xinyu Chen, Steven P. Rowe, -1

机译：进入PET心肌灌注成像的下一个时代：新型18F标记示踪剂的引入
7. Myocardial tissue perfusion determined by particulate and diffusible tracers during ischaemia: what is measured? [O] . D. S. Fluck, P. J.E. Etherington, D. OHare, 1996

机译：心肌组织灌注通过粒状期间的颗粒状和扩散示踪剂测定：测量什么？
8. Novel, Convenient, and Nonpersistent Radiotracer for Environmental and Energy Applications [R] . Grant, P. M. 1984

机译：用于环境和能源应用的新型，方便和非持久性放射性示踪剂

A Convenient Route to 68GaGa-MAA for Use as a Particulate PET Perfusion Tracer

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