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NONINVASIVE ULTRASOUND ELASTICITY IMAGING (UEI) OF CROHN’S DISEASE: ANIMAL MODEL

机译：克罗恩病的非侵入性超声弹性成像（UEI）：动物模型

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Inflammation occurs in episodic flares in Crohn’s disease, which are part of the waxing and waning course of the disease. Healing between flares allows the intestine to reconstitute its epithelium, but this healing results in the deposition of fibrotic scar tissue as part of the healing process. Repeated cycles of flares and healing often lead to clinically significant fibrosis and stenosis of the intestine. Patients are treated empirically with steroids, with their many side effects, in the hope that they will respond. Many patients would be better treated with surgery if we could identify which patients truly have intestinal fibrosis. Ultrasound elasticity imaging (UEI) offers the potential to radically improve the diagnosis and management of local tissue elastic property, particularly intestinal fibrosis. This method allows complete characterization of local intestine tissue with high spatial resolution. The feasibility of UEI on Crohn’s disease is demonstrated by directly applying this technique to an animal model of inflammatory bowel disease (IBD). Five female Lewis rats (150 –180g) were prepared with phosphate buffered solution (PBS) as a control group and six were prepared with repeated intrarectal administration of trinitrobenzenesulfonic acid (TNBS) as a disease group. Preliminary strain measurements differentiate the diseased colons from the normal colons (p < 0.0002) and compared well with direct mechanical measurements and histology (p < 0.0005). UEI provides a simple and accurate assessment of local severity of fibrosis. The preliminary results on an animal model also suggest the feasibility of translating this imaging technique directly to human subjects for both diagnosis and monitoring.
机译：炎症发生在克罗恩病的发作性发作中，这是该病病情恶化的一部分。耀斑之间的愈合可以使肠重构其上皮，但是这种愈合会导致纤维化疤痕组织沉积，这是愈合过程的一部分。反复发作和愈合通常会导致临床上明显的肠纤维化和狭窄。患者接受类固醇激素治疗，具有许多副作用，希望他们能做出反应。如果我们能够确定哪些患者确实患有肠道纤维化，那么对许多患者进行手术治疗会更好。超声弹性成像（UEI）提供了从根本上改善局部组织弹性，尤其是肠纤维化的诊断和管理的潜力。该方法允许以高空间分辨率完整表征局部肠组织。通过将这种技术直接应用于炎症性肠病（IBD）动物模型，可以证明UEI在克罗恩病上的可行性。制备五只雌性Lewis大鼠（150 – 180g），用磷酸盐缓冲液（PBS）作为对照组，制备六只经直肠内反复施用三硝基苯磺酸（TNBS）的动物作为疾病组。初步应变测量可将患病结肠与正常结肠区分开（p <0.0002），并与直接机械测量和组织学进行比较（p <0.0005）。 UEI提供了局部纤维化严重程度的简单而准确的评估。动物模型的初步结果还表明，将这种成像技术直接转化为人类受试者进行诊断和监测的可行性。

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