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Impact of Intermittent Preventive Anti-Malarial Treatment on the Growth and Nutritional Status of Preschool Children in Rural Senegal (West Africa)

机译:间歇性预防性抗疟疾治疗对塞内加尔农村(西非)学龄前儿童生长和营养状况的影响

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摘要

Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on growth and nutritional status in 1,063 Senegalese preschool children. A combination of artesunate and sulfadoxine-pyrimethamine was given monthly from September to November. In the intervention arm, mean weight gain was significantly greater (122.9 ± 340 versus 42.9 ± 344 [SD] g/mo, P < 0.0001) and losses in triceps and subscapular skinfold measurements were less (−0.39 ± 1.01 versus −0.66 ± 1.01 mm/mo, and −0.15 ± 0.64 versus −0.36 ± 0.62 mm/mo, respectively, P < 0.0001 for both). There was no difference in height increments. The prevalence of wasting increased significantly in the control arm (4.6% before versus 9.5% after, P < 0.0001), but remained constant in intervention children: 5.6% versus 7.0% (P = 0.62). The prevention of malaria would improve child nutritional status in areas with seasonal transmission.
机译:疟疾的负面影响可能是萨赫勒地区儿童营养状况的季节性因素。我们报告了一项季节性,双盲,安慰剂对照的季节性间歇性预防性抗疟疾治疗对1,063名塞内加尔学龄前儿童的生长和营养状况的影响。从9月至11月每月给予一次青蒿琥酯和磺胺多辛-乙胺嘧啶的组合。在干预组中,平均体重增加明显更大(122.9±340比42.9±344 [SD] g / mo,P <0.0001),三头肌和肩s下皮褶测量的损失更少(-0.39±1.01比-0.66±1.01) mm / mo和-0.15±0.64对-0.36±0.62 mm / mo,两者均P <0.0001)。高度增量没有差异。对照组的浪费发生率显着增加(之前为4.6%,之后为9.5%,P <0.0001),但在干预儿童中保持不变:5.6%对7.0%(P = 0.62)。预防疟疾将改善季节性传播地区儿童的营养状况。

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