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Light scattering experiments on aqueous solutions of selected cellulose ethers: contribution to the study of polymer-mineral interactions in a new injectable biomaterial

机译：选定纤维素醚水溶液的光散射实验：对新型可注射生物材料中聚合物与矿物相互作用的研究的贡献

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Hydroxypropylmethylcellulose (HPMC) is used as a ligand for a bioactive calcium phosphate ceramic (the filler) in a ready-to-use injectable sterilized biomaterial for bone and dental surgery. Light scattering experiments were usually used to study high water-soluble polymers and to determine the basic macromolecular parameters. In order to gain a deeper understanding of polymer/mineral interactions in this type of material, we have investigated the effect of divalent and trivalent ions (Ca2+, PO43−) and steam sterilization on dilute solutions of HPMC and HEC. The sterilization process may cause some degradation of HEC taking into account its high molecular weight and some rigidity of the polymer chain. Moreover, in the case of HPMC, the changes in the conformations rather than degradation process are supposed. These effects of degradation and flocculation are strengthened in alkaline medium. Experimental data suggested the formation of chelate complexes between Ca2+ and HPMC which improve its affinity to the mineral blend and consolidate the injectable biomaterial even in the case of its hydration by biological fluid.
机译：羟丙基甲基纤维素（HPMC）在用于骨骼和牙科手术的即用型可注射灭菌生物材料中，用作生物活性磷酸钙陶瓷（填充剂）的配体。通常使用光散射实验来研究高水溶性聚合物并确定基本的大分子参数。为了更深入地了解此类材料中的聚合物/矿物相互作用，我们研究了二价和三价离子（Ca 2 + ，PO4 3 − ）和HPMC和HEC的稀溶液进行蒸汽灭菌。考虑到其高分子量和聚合物链的某些刚性，灭菌过程可能会导致HEC的某些降解。此外，在HPMC的情况下，假定构象发生变化而不是降解过程。在碱性介质中，降解和絮凝的这些作用得到增强。实验数据表明，Ca 2 + 与HPMC之间形成螯合物，即使在生物液水合的情况下，也能改善其对矿物掺合物的亲和力并巩固可注射生物材料。

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