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首页> 美国卫生研究院文献>Acta Pharmaceutica Sinica. B >A systematic strategy for screening therapeutic constituents of Schisandra chinensis (Turcz.) Baill infiltrated blood–brain barrier oriented in lesions using ethanol and water extracts: a novel perspective for exploring chemical material basis of herb medicines
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A systematic strategy for screening therapeutic constituents of Schisandra chinensis (Turcz.) Baill infiltrated blood–brain barrier oriented in lesions using ethanol and water extracts: a novel perspective for exploring chemical material basis of herb medicines

机译：利用乙醇和水提取物筛选北五味子治疗的五味子浸润性血脑屏障的系统策略：探索草药化学物质基础的新视角

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摘要

, a widely used Chinese herbal medicine, was considered as central nervous system (CNS) drug for years. Both ethanol extracts (EES) and water extracts (WES) of it were applied clinically. Unfortunately, the difference of their efficacy and even effective material foundation of remains obscure. In this study, to explore the active constituents of , we compared pharmacodynamics and chemical profiles / of EES/WES for the first time using multiple chemical analysis, pharmacological and data processing approaches. It was proved that there was no significant difference in the anti-depressive effects between WES and EES. However, the contents of most components and in plasma were higher in EES than those in WES, which was unconvincing for their similar efficacy. Therefore, we further explored components of targeted onto brain and the results showed that 5 lignans were identified with definite absorptivity respectively both in EES and WES caused by the limitation of blood−brain barrier. Moreover, bioinformatic analysis predicted their anti-depressive action. Above all, the systematic strategy screened 5 brain-targeted effective substances of and it was suggested that exploring the components into nidi would promote the studies on herbs effective material basis.
机译：，一种广泛使用的中草药，多年来一直被视为中枢神经系统（CNS）药物。其乙醇提取物（EES）和水提取物（WES）均已在临床上应用。不幸的是，它们的功效甚至有效物质基础的差异仍然不清楚。在这项研究中，为了探索的活性成分，我们首次使用多种化学分析，药理学和数据处理方法比较了EES / WES的药效学和化学概况。事实证明，WES和EES之间的抗抑郁作用没有显着差异。然而，EES中大多数成分和血浆中的含量均高于WES中，这对于它们的相似功效并不令人信服。因此，我们进一步探索了靶向大脑的成分，结果表明，由于血脑屏障的限制，在EES和WES中分别鉴定出5种木脂素具有确定的吸收性。此外，生物信息学分析预测了它们的抗抑郁作用。最重要的是，该系统策略筛选了5种针对大脑的有效物质，并建议探索尼迪成分，将促进以草药有效物质为基础的研究。

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