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首页> 美国卫生研究院文献>Aging (Albany NY) >Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy
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Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy

机译：白藜芦醇通过激活线粒体吞噬来延缓小鼠卵母细胞的排卵后衰老。

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摘要

Resveratrol (3,5,4′-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a potential mechanism to protect against postovulatory oocyte aging.
机译：白藜芦醇（3,5,4'-三羟基sti，RSV）是一种天然的潜在抗衰老多酚化合物，经常用作抗多种疾病的营养补充剂。然而，白藜芦醇调节卵母细胞排卵后衰老的基本机制仍然是未知的。在这项研究中，我们发现白藜芦醇可以通过激活小鼠的选择性吞噬作用来延迟排卵后的衰老并改善卵母细胞的发育能力。白藜芦醇可以维持纺锤体形态，但在卵母细胞衰老过程中会干扰皮质颗粒（CG）的分布。这可能是由于线粒体的上调引起的，因为通过环孢菌素A（CsA）处理阻止线粒体的生长会通过破坏线粒体功能来影响卵母细胞的质量，并降低胚胎发育。此外，我们还观察到白藜芦醇治疗后FoxO3a参与调节衰老卵母细胞的线粒体。两者合计，我们的结果提供证据，白藜芦醇诱导的线粒体是防止排卵后卵母细胞衰老的潜在机制。

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