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首页> 美国卫生研究院文献>Animal Nutrition >A Saccharomyces cerevisiae RC016-based feed additive reduces liver toxicity residual aflatoxin B1 levels and positively influences intestinal morphology in broiler chickens fed chronic aflatoxin B1-contaminated diets
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A Saccharomyces cerevisiae RC016-based feed additive reduces liver toxicity residual aflatoxin B1 levels and positively influences intestinal morphology in broiler chickens fed chronic aflatoxin B1-contaminated diets

机译：基于酿酒酵母RC016的饲料添加剂可降低饲喂受黄曲霉毒素B1污染的日粮的肉鸡的肝脏毒性黄曲霉毒素B1的残留水平并积极影响肠道形态

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The present study was conducted to investigate the ability of RC016 (Sc)-based feed additive to reduce liver toxicity, residual aflatoxin B (AFB ) levels and influence intestinal structure in broiler chickens fed chronic aflatoxin B -contaminated diets. A total of 100 one-day-old male commercial line (Ross) broiler chickens were divided into 4 treatments, with 5 pens per treatment and 5 broiler chickens per pen. Birds were randomly assigned to 4 treatments, which were namely treatment 1 (T ), control diet (CD); T , CD + Sc at 1 g/kg; T , CD + AFB at 100 μg/kg; T , CD + Sc at 1 g/kg + AFB at 100 μg/kg. The liver histopathology of broiler chickens fed diets with AFB showed diffused microvacuolar fatty degeneration. The addition of Sc showed normal hepatocytes similar to the control. The small intestine villi from AFB group showed atrophy, hyperplasia of goblet cells, prominent inflammatory infiltrate and oedema. In contrast, the small intestine villi from birds that received the yeast plus AFB showed an absence of inflammatory infiltrate, and atrophy; moreover, a lower number of goblet cells compared to the groups with AFB was observed. The morphometric intestine studies showed that a significant decrease (  0.05) in the crypt depth values when Sc was applied to AFB -contaminated diets. Although the intestinal villus height and apparent adsorption area did not show significant differences (  0.05), there was a tendency to improve these parameters. The residual levels of AFB in livers were significantly reduced (  0.05) in the presence of the yeast. The present work demonstrated that the addition of Sc alone or in combination with AFB in the broiler chicken diets had a beneficial effect in counteracting the toxic effects of AFB in livers besides improving the histomorphometric parameters and modulating the toxic effect of AFB in the intestine.
机译：进行本研究以研究基于RC016（Sc）的饲料添加剂在饲喂受慢性黄曲霉毒素B污染的日粮中降低肝脏毒性，残留黄曲霉毒素B（AFB）水平并影响肠道结构的能力。将总共​​100只1日龄雄性商品线（Ross）肉鸡分为4种处理方法，每种处理5支，每支5只。鸟类被随机分配给4种处理，即处理1（T），对照饮食（CD）； T，CD + Sc为1 g / kg; T，CD + AFB为100μg/ kg; T，CD + Sc为1 g / kg + AFB为100μg/ kg。饲喂AFB日粮的肉鸡的肝脏组织病理学表现为弥散性微血管脂肪变性。添加Sc显示正常肝细胞与对照相似。 AFB组的小肠绒毛表现出萎缩，杯状细胞增生，炎性浸润和水肿。相反，接受了酵母加AFB的鸟类的小肠绒毛则没有炎症浸润和萎缩。此外，与具有AFB的组相比，观察到杯状细胞的数量更少。形态肠道研究表明，将Sc应用于受AFB污染的饮食时，隐窝深度值显着降低（≥0.05）。尽管肠绒毛高度和表观吸附面积没有显示出显着差异（0.05），但存在改善这些参数的趋势。在存在酵母的情况下，肝脏中AFB的残留水平显着降低（0.05）。目前的工作表明，在肉鸡日粮中单独添加Sc或与AFB结合使用，除了改善组织形态测定参数和调节AFB在肠中的毒性作用外，还具有抵消AFB对肝脏的毒性作用的有益作用。

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