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Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine β-casein gene locus

机译：组蛋白脱乙酰基酶抑制剂和RAD51重组酶增加牛β-酪蛋白基因位点上转录激活子样效应子核酸酶介导的同源重组

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摘要

The efficiency of the knock-in process is very important to successful gene editing in domestic animals. Recently, it was reported that transient loosening of the nucleosomal folding of transcriptionally inactive chromatin might have the potential to enhance homologous recombination efficiency. The objective of this study was to determine whether histone deacetylases (HDAC) inhibitor and RAD51 recombinase (RAD51) expression were associated with increased knock-in efficiency on the β-casein ( ) gene locus in mammary alveolar-large T antigen (MAC-T) cells using the transcription activator-like effector nucleases (TALEN) system.

机译：敲入过程的效率对于家畜成功进行基因编辑非常重要。最近，据报道，转录失活的染色质的核小体折叠的暂时性松动可能具有增强同源重组效率的潜力。这项研究的目的是确定组蛋白脱乙酰基酶（HDAC）抑制剂和RAD51重组酶（RAD51）的表达是否与提高乳腺肺泡大T抗原（MAC-T）的β-酪蛋白（）基因位点的敲入效率有关。细胞），使用转录激活因子样效应核酸酶（TALEN）系统。

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期刊名称 Asian-Australasian Journal of Animal Sciences
作者
Da Som Park; Se Eun Kim; Deog-Bon Koo; Man-Jong Kang;
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作者单位

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年(卷),期 2020(33),6
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类动物学;
关键词
Knock-in; Histone Deacetylases (HDAC) Inhibitor; Homologous Recombination (HR); RAD51 recombinase (RAD51); Transcription Activator-like Effector Nucleases (TALEN);

机译：敲入;组蛋白脱乙酰基酶（HDAC）抑制剂;同源重组（HR）;RAD51重组酶（RAD51）;转录激活因子样效应核酸酶（TALEN）;

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专利

1. Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine beta-casein gene locus [J] . Asian-Australasian Journal of Animal Sciences . 2020,第6期

机译：组蛋白脱乙酰酶抑制剂和RAD51重组酶增加转录活化剂样效应器核酸酶介导在牛酪蛋白基因基因座上的同源重组
2. Generation of Fibroblasts Lacking the Sal-like 1 Gene by Using Transcription Activator-like Effector Nuclease-mediated Homologous Recombination [J] . Kim Se Eun, Kim Ji Woo, Kim Yeong Ji, Asian-Australasian Journal of Animal Sciences . 2016,第4期

机译：通过使用转录激活因子样效应物核酸酶介导的同源重组缺乏Sal样1基因的成纤维细胞的生成。
3. Engineered nucleases-mediated in situ correction of a genetic defect by homologous recombination into the native locus [J] . Latella M. C., De Rosa L., Miselli F., Human gene therapy . 2016,第11期

机译：通过同源重组进入天然基因座的工程核酸酶介导的遗传缺陷的原位校正
4. Effects of histone deacetylase inhibitor Trichostatin A on epigenetic changes and transcriptional activation of Bdnf promoter 1 by rat hippocampal neurons [C] . Feng Tian, Ann M. Marini, Robert H. Lipsky International Conference on Neuroprotective Agents: Clinical and Experimental Aspects . 2010

机译：组蛋白脱乙酰化酶抑制剂richostatinα对大鼠海马神经元对BDNF启动子1的表观遗传学变化及转录激活的影响
5. Regulation of the Rad51 recombinase in homologous recombination. [D] . Seong, Changhyun. 2009

机译：Rad51重组酶在同源重组中的调控。
6. CBP and p300 Histone Acetyltransferases Contribute to Homologous Recombination by Transcriptionally Activating the BRCA1 and RAD51 Genes [O] . Hideaki Ogiwara, Takashi Kohno 2009

机译：CBP和p300组蛋白乙酰基转移酶通过转录激活BRCA1和RAD51基因来促进同源重组。
7. Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine β-casein gene locus [O] . Da Som Park, Se Eun Kim, Deog-Bon Koo, 2020

机译：组蛋白脱乙酰酶抑制剂和Rad51重组酶增加转录活化剂样效应器核酸酶介导的牛β-酪蛋白基因座上的同源重组

Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine β-casein gene locus

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