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One-pot synthesis of substituted pyrrolo34-bpyridine-45-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines

机译：基于N-（1-（4-羟基-6-甲基-2-氧-2-氧-2H-吡喃-3-）的反应一锅合成取代的吡咯并34-b吡啶-45-二酮胺基）-2-氧代-2-芳基乙基）乙酰胺

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摘要

The condensation of primary amines with -(1-(4-hydroxy-6-methyl-2-oxo-2 -pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine, which provided the corresponding dihydropyrrolone derivative as the major reaction product. Based on this transformation, a practical and convenient one-pot synthetic method for substituted pyrrolo[3,4- ]pyridin-5-ones could be devised.

机译：研究了伯胺与-（1-（4-羟基-6-甲基-2-氧代-2-吡喃-3-基）-2-氧代-2-芳基乙基）乙酰胺的缩合。因此，在胺存在下在酸性乙醇中观察到原料的先前未知的再循环，这提供了相应的二氢吡咯烷酮衍生物作为主要反应产物。基于这种转化，可以设计出一种实用，方便的一锅合成吡咯并[3,4-]吡啶-5-酮的方法。

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期刊名称 Beilstein Journal of Organic Chemistry
作者
Valeriya G Melekhina; Andrey N Komogortsev; Boris V Lichitsky; Vitaly S Mityanov; Artem N Fakhrutdinov; Arkady A Dudinov; Vasily A Migulin; Yulia V Nelyubina; Elizaveta K Melnikova; Michail M Krayushkin;
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作者单位

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年(卷),期 2019(15),-1
年度 2019
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
condensation; dihydropyrrolone derivative; one-pot synthesis; pyrrolo34-;

机译：缩合;二氢吡咯烷酮衍生物;一锅合成;吡咯并34-;

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1. Organic amine-mediated free-radical carbocyclization reactions of 2,2,2-trihalogeno- substituted N-(2-alkynylphenyl)acetamides [J] . Chuang Tsung-Han, Chuang Che-Ping Organic & biomolecular chemistry . 2018,第39期

机译：2,2,2-三卤代N-（2-炔基苯基）乙酰胺的有机胺介导的自由基碳环化反应
2. A Practical Synthesis of the TGF beta RI Inhibitor N-(4-(3-(6-(Difluoromethyl)pyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl)pyridin-2-yl)acetamide via One-Pot Sequential Sonogashira and Cacchi Reactions Catalyzed by Pd(OAc)(2)/BINAP [J] . Li Jianqing, Smith Daniel, Krishnananthan Subramaniam, Organic process research & development . 2020,第3期

机译：TGFβRI抑制剂N-（4-（3-（二氟甲基）吡啶-2-基）-1H-吡咯的[3,2-B]吡啶-2-基）Pyridin-2-的实际合成 YL）乙酰胺通过单盆顺序Sonogashira和Caccli反应催化Pd（OAC）（2）/ binap催化
3. Synthesis of novel Schiff base N-[(E)-1-(1H-indole-3-yl)methylidene]-N-[4-(4-{[(E)-1-(1H-indol-3-yl)methylidene]amino} phenoxy)phenyl] amine [J] . A. A. Jarrahpour, M. Zarei Molbank . 2004,第1期

机译：新型席夫碱N-[（E）-1-（1H-吲哚-3-基）亚甲基] -N- [4-（4-{[（E）-1-（1H-吲哚-3-基）]的合成）亚甲基]氨基}苯氧基）苯基]胺
4. One-pot synthesis of azetidine-2,4-diones via multicomponent reaction of an amine, an acetylenic compound, and an arylsulfonyl isocyanate [C] . Atieh Rezvanian, Abdolali Alizadeh European Symposium on Organic Chemistry . 2009

机译：通过胺，乙酰烯烯化合物和芳基磺基异氰酸酯的多组分反应的氮丁胺-2,4-二乙醚的单壶合成
5. Hydrozirconation/zirconium-zinc transmetalation/aldimine addition: One-pot synthesis of allylic, c-cyclopropylalkyl, and homoallylic amine from alkynes. [D] . Kendall, Christopher Nicholas Owen. 2004

机译：加氢锆/锆锌金属转移/醛亚胺的添加：从炔烃一锅法合成烯丙基，c-环丙基烷基和均烯丙基胺。
6. Acid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly ofImidazo45-cquinolin-2-one [O] . Xiao Lu, Myunghoon Kim, Meghan J. Orr, -1

机译：N-（4-氯喹啉-3-基）氨基甲酸酯与胺的酸促进级联反应：一锅组装的咪唑并45-c喹啉-2-一
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机译：新型席夫碱N - [（E）-1-（1H-吲哚-3-基）亚甲基] -N- [4-（4 - {[（E）-1-（1H-吲哚-3-基）]的合成亚甲基]氨基}苯氧基）苯基]胺

One-pot synthesis of substituted pyrrolo34-bpyridine-45-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines

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