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首页> 美国卫生研究院文献>Journal of Clinical and Translational Science >2437 A prospective study of cancer clinical trial availability and enrollment among adolescents/young adults treated at a Children’s Hospital or Affiliated Adult Cancer Specialty Hospital
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2437 A prospective study of cancer clinical trial availability and enrollment among adolescents/young adults treated at a Children’s Hospital or Affiliated Adult Cancer Specialty Hospital

机译：2437前瞻性研究在儿童医院或附属成人癌症专科医院接受治疗的青少年/年轻人中癌症临床试验的可获得性和纳入

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OBJECTIVES/SPECIFIC AIMS: Low cancer clinical trial (CCTs) enrollment may contribute to the poor survival improvement for adolescents and young adults (AYAs, aged 15–39 years) with cancer. Treatment site is thought to exacerbate this problem. This study evaluated whether differences in CCT availability explain lower CCT enrollment depending on treatment site for AYAs. METHODS/STUDY POPULATION: This prospective, observational cohort study was conducted at an academic children’s hospital and an adult cancer hospital, 2 affiliated sites within a NCI-designated Comprehensive Cancer Center over 13 months. In consecutive AYA patients newly diagnosed with cancer at both site, it was determined whether an appropriate CCT existed nationally, was available locally, and if enrollment occurred. The proportions of AYAs in these categories were compared by site using the χ2 test. RESULTS/ANTICIPATED RESULTS: Among 152 consecutive AYA patients, 68 and 84 were treated at the children’s hospital and adult cancer hospital, respectively. AYAs treated at the children’s hospital had similar CCT existence nationally compared with AYAs treated at the adult hospital [36/68 (52.9%) vs. 45/84 (53.6%), p=0.938]. However, a significantly higher percentage of children’s hospital treated AYAs than adult hospital treated AYAs had an available CCT [30/68 (44.1%) vs. 14/84 (16.7%), p<0.001]. Enrollment percentages were similarly low in both groups [8/68 (11.8%) vs. 6/84 (7.1%), p=0.327]. DISCUSSION/SIGNIFICANCE OF IMPACT: Significantly fewer AYAs treated at the adult hospital had a CCT available, but national existence was similar at both sites. This suggests that institutional barriers to opening CCT have more importance at adult centers.
机译：目的/特定目的：参加低癌症临床试验（CCT）可能会导致青少年癌症患者的青少年生存率提高（15岁至39岁）。治疗部位被认为加剧了这个问题。这项研究评估了CCT可用性的差异是否解释了根据AYAs治疗部位的不同，CCT登记人数较低。方法/研究人群：这项前瞻性，观察性队列研究是在13个月内，在NCI指定的综合癌症中心的两个附属站点的学术儿童医院和成人癌症医院进行的。在两个地点都被新近诊断出患有癌症的连续AYA患者中，确定全国是否存在适当的CCT，在当地是否有适当的CCT以及是否进行了入组。使用χ 2 检验按地点比较这些类别中AYA的比例。结果/预期结果：连续152例AYA患者中，有68例和84例分别在儿童医院和成人癌症医院接受了治疗。与成人医院治疗的AYA相比，儿童医院治疗的AYA在全国范围内的CCT存在率相似[36/68（52.9％）对45/84（53.6％），p = 0.938]。但是，有儿童接受CCT的儿童医院接受治疗的AYAs的比例明显高于成人医院接受治疗的AYAs [30/68（44.1％）vs. 14/84（16.7％），p <0.001]。两组的入学率均较低[8/68（11.8％）与6/84（7.1％），p = 0.327]。讨论/意义：在成人医院接受CCC治疗的AYA明显减少，但在两个地点的民族存在情况相似。这表明在成人中心，开放CCT的制度性障碍更为重要。

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