Celebration of the 50-Year Anniversary of the National Heart Lung and Blood Institute Division of Lung Diseases: A Half-Century of Landmark Clinical Trials

机译：庆祝美国国家心肺和血液研究所肺病科成立50周年：具有里程碑意义的临床试验半个世纪

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The National Institutes of Health (NIH)-National Heart, Lung, and Blood Institute’s (NHLBI) Division of Lung Diseases is celebrating its 50 anniversary. On this occasion, we are reviewing the major landmark clinical trials that were initiated by the NHLBI’s Division of Lung Disease and that have had substantial impact on our understanding of chronic obstructive pulmonary disease (COPD) and how it is best treated. Although some of these trials did not show hypothesized treatment benefits for COPD, they have enabled clinicians to provide care for individuals with COPD relying on the most rigorous evidence. The 5 trials that are reviewed here are: the Intermittent Positive Pressure Breathing Trial, the Nocturnal Oxygen Treatment Trial, the Lung Health Study, the National Emphysema Treatment Trial, and the Long-term Oxygen Treatment Trial. These clinical trials have not only set the standards for COPD care but have served as models for the state-of-the-art conduct of clinical research in COPD.

机译：美国国立卫生研究院（NIH）-美国国家心，肺和血液研究所（NHLBI）的肺病科正在庆祝其成立50周年。在此情况下，我们正在审查由NHLBI肺病科发起的主要里程碑式临床试验，这些试验对我们对慢性阻塞性肺疾病（COPD）的理解及其最佳治疗方法具有重大影响。尽管其中一些试验并未显示出对COPD的假设治疗益处，但它们使临床医生能够依靠最严格的证据为COPD患者提供治疗。这里审查的5个试验是：间歇性正压呼吸试验，夜间氧气治疗试验，肺健康研究，国家肺气肿治疗试验和长期氧气治疗试验。这些临床试验不仅为COPD护理设定了标准，而且已成为COPD临床研究的最新模式。

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期刊名称 Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
作者
Robert A. Wise; Jerry A. Krishnan;
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作者单位

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年(卷),期 2019(6),4
年度 2019
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类生理学;
关键词
copd; chronic obstructive pulmonary disease; clinical trials; lung volume reduction surgery; oxygen therapy; smoking cessation; positive pressure breathing;

机译：慢性阻塞性肺疾病;临床试验;肺减容术;氧气治疗;戒烟;正压呼吸;

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专利

1. NHLBI at 50: reflections on a half-century of research on the heart, lungs, and blood. National Heart, Lung, and Blood Institute (interview by Charles Marwick) [J] . Lenfant C JAMA: the Journal of the American Medical Association . 1998,第24期

机译：NHLBI 50岁：对心脏，肺和血液的半个世纪研究的反思。国家心脏，肺和血液研究所（Charles Marwick访谈）
2. National Heart, Lung, and Blood Institute resources and programs for gene therapy in heart, lung, and blood diseases. [J] . Skarlatos SI Circulation research: a journal of the American Heart Association . 2007,第12期

机译：美国国家心脏，肺和血液研究所的资源和计划可用于心脏，肺和血液疾病的基因治疗。
3. Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network. [J] . Denlinger LC, Sorkness CA, Chinchilli VM, The Journal of Allergy and Clinical Immunology . 2007,第1期

机译：美国国家心，肺和血液研究所哮喘临床研究网络和儿童哮喘研究与教育网络的指南定义性哮喘临床试验。
4. Effects of CT dose and nodule characteristics on lung-nodule detectability in a cohort of 90 National Lung Screening Trial patients. [C] . Stefano Young, Pechin Lo, John M. Hoffman, Conference on medical imaging . 2016

机译：CT剂量和结节特征对90例国家肺癌筛查试验患者队列中肺结节可检测性的影响。
5. Analysis of Patient Recruitment Methods for Clinical Trials of Different Heart and Lung Diseases [D] . Sido, Oghenevovwero Vovwe. 2018

机译：不同心脏和肺部疾病临床试验的患者招募方法分析
6. A Randomized Controlled Trial of Low Dose Hormone Therapy on Myocardial Ischemia in Postmenopausal Women with No Obstructive Coronary Artery Disease: Results from the National Institutes of Health – National Heart Lung and Blood Institute (NHLBI) – Sponsored Women’s Ischemia Syndrome Evaluation (WISE) [O] . C. Noel Bairey Merz, Marian B. Olson, Candace McClure, -1

机译：一项随机对照低剂量激素治疗试验对心肌缺血的绝经后妇女没有阻塞性冠状动脉疾病：由美国国立卫生研究院结果 - 国家心脏肺和血液研究所（NHLBI） - 赞助妇女缺血综合征评估（WIsE）
7. Relation Between Clinical, Angiographic and Ischemic Findings at Baseline and Ischemia-Related Adverse Outcomes at 1 Year in the Asymptomatic Cardiac Ischemia Pilot Studyfn1This study was funded by the National Heart, Lung, and Blood Institute, Cardiac Diseases Branch, Division of Heart and Vascular Diseases, National Institutes of Health, Bethesda, Maryland, by Research Contracts HV-90-07, HV90-08, HV-91-05 to HV-91-14. Study medications and placebo were donated by Zeneca Pharmaceuticals Group, Wilmington, Delaware; Marion-Merrell Dow, Kansas City, Missouri; and Pfizer, New York, New York. Support for electrocardiographic data collection was provided in part by Applied Cardiac Systems, Laguna Hills, California; Marquette Electronics, Milwaukee, Wisconsin; Mortara Instrument, Milwaukee, Wisconsin; and Quinton Instruments, Seattle, Washington. Some centers had partial support from grants from the General Clinical Research Center, National Institutes of Health. [O] . University of Florida, College of Medicine, Division of Cardiology, Gainesville, Florida, USA. ( host institution ), Pepine, Carl J., Sharaf, Barry, 1997

机译：无症状性心脏缺血性先导研究在基线时的临床，血管造影和缺血性发现与1年时与缺血相关的不良结果之间的关系本研究由美国国家心脏病，肺和血液研究所，心脏疾病和血管病科心脏疾病分会资助，位于美国马里兰州贝塞斯达（Bethesda）的美国国立卫生研究院（National Institutes of Health），依据研究合同HV-90-07，HV90-08，HV-91-05至HV-91-14。研究药物和安慰剂由特拉华州威明顿市的Zeneca制药集团捐赠；密苏里州堪萨斯城的Marion-Merrell Dow；辉瑞公司，纽约，纽约。加州拉古纳山的Applied Cardiac Systems部分提供了对心电图数据收集的支持。威斯康星州密尔沃基市的Marquette Electronics；威斯康星州密尔沃基的Mortara Instrument公司；昆顿仪器公司，华盛顿州西雅图市。一些中心得到了美国国立卫生研究院普通临床研究中心的部分资助。
8. National Heart, Lung and Blood Institute Report of the Task Force on BehavioralResearch in Cardiovascular, Lung, and Blood Health and Disease [R] . 1998

机译：国家心肺血液研究所心血管，肺，血液健康与疾病行为研究专题组报告

Celebration of the 50-Year Anniversary of the National Heart Lung and Blood Institute Division of Lung Diseases: A Half-Century of Landmark Clinical Trials

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