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Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease

机译：神经性莱姆病患者脑脊液中Decorin结合蛋白B（BBA25）和BBA50抗体的优先存在

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摘要

Borrelia burgdorferi antibodies preferentially present in cerebrospinal fluid (CSF) were examined by differentially probing a B. burgdorferi expression library with CSF and sera from patients with neurologic Lyme disease. Several phage clones selectively reacted with CSF, and these genes were then expressed in recombinant form and used to detect specific antibody in an enzyme-linked immunosorbent assay. Decorin-binding protein B (BBA25) and BBA50 (hypothetical protein) elicited immunoglobulin G (IgG) or IgM detectable in CSF—but not sera—of patients, demonstrating preferential antibody production during neuroborreliosis.

机译：优先存在于脑脊液（CSF）中的伯氏疏螺旋体抗体通过对具有神经系统莱姆病患者的伯氏疏螺旋体表达文库与CSF和血清进行差异探测来进行检查。几个噬菌体克隆与CSF选择性反应，然后这些基因以重组形式表达，并用于在酶联免疫吸附测定中检测特异性抗体。 Decorin结合蛋白B（BBA25）和BBA50（假设蛋白）引发了在患者的CSF（而非血清）中可检测到的免疫球蛋白G（IgG）或IgM，证明了在神经硼蛋白病期间优先产生抗体。

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期刊名称 Journal of Clinical Microbiology
作者
Erol Fikrig; Patricia K. Coyle; Steven E. Schutzer; Manchuan Chen; Zhidian Deng; Richard A. Flavell;
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作者单位

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年(卷),期 2004(42),3
年度 2004
页码 1243–1246
总页数 4
原文格式 PDF
正文语种
中图分类微生物学;
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专利

1. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease [J] . Erol Fikrig, Patricia K. Coyle, Steven E. Schutzer, Journal of Clinical Microbiology . 2004,第3期

机译：神经性莱姆病患者脑脊液中Decorin结合蛋白B（BBA25）和BBA50抗体的优先存在
2. Antibodies to recombinant decorin-binding proteins A and B in the cerebrospinal fluid of patients with Lyme neuroborreliosis. [J] . Panelius J, Sillanpaa H, Seppala I, Scandinavian journal of infectious diseases. . 2007,第9期

机译：莱姆病（Lyme Neuroborreliosis）患者脑脊液中重组除蛋白结合蛋白A和B的抗体。
3. Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease [J] . Emma G. Stafford, Amanda Kortum, Aude Castel, Journal of Veterinary Internal Medicine . 2019,第5期

机译：在患有神经系统疾病的犬中与人自身免疫性脑炎相关的脑脊髓液抗体的存在
4. Exacerbation of amyloid beta peptide and Tau protein in the cerebrospinal fluid following Traumatic Brain Injury at Hot Environment Neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies [C] . Hari Shanker Sharma, Jose V Lafuente, Dafin F Muresanu, Annual techconnect world innovation conference expo;Defense techconnect DTS conference;Annual nanotech conference expo;SBIR/STTR innovation conference . 2018

机译：在Tau抗体的TiO2纳米线传递下脑溶素的热环境神经保护下颅脑损伤后颅脑液中淀粉样β肽和Tau蛋白的加重。
5. Bioinformatic analysis of exosomal cerebrospinal fluid proteins in late stages of Alzheimer's disease [D] . Alkaraki, Almuthanna Khalaf Ahmed. 2015

机译：阿尔茨海默氏病晚期外泌体脑脊液蛋白的生物信息学分析
6. Presence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease [O] . Emma G. Stafford, Amanda Kortum, Aude Castel, 2019

机译：在患有神经系统疾病的犬中存在与人自身免疫性脑炎相关的脑脊髓液抗体
7. Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease [O] . Fikrig, Erol, Coyle, Patricia K., Schutzer, Steven E., 2004

机译：神经性莱姆病患者脑脊液中Decorin结合蛋白B（BBA25）和BBA50抗体的优先存在

Preferential Presence of Decorin-Binding Protein B (BBA25) and BBA50 Antibodies in Cerebrospinal Fluid of Patients with Neurologic Lyme Disease

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